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MF(ALPHA)1 / YPL187W Literature
All manually curated literature for the specified gene, organized by relevance to the gene and by
association with specific annotations to the gene in SGD. SGD gathers references via a PubMed search for
papers whose titles or abstracts contain “yeast” or “cerevisiae;” these papers are reviewed manually and
linked to relevant genes and literature topics by SGD curators.
- Unique References
- 217
- Aliases
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alpha-factor
Primary Literature
Literature that either focuses on the gene or contains information about function, biological role,
cellular location, phenotype, regulation, structure, or disease homologs in other species for the gene
or gene product.
No primary literature curated.
Download References (.nbib)
- Zeng L, et al. (2022) Transcriptomic analysis of formic acid stress response in Saccharomyces cerevisiae. World J Microbiol Biotechnol 38(2):34 PMID:34989900
- Bossak K, et al. (2016) Interactions of α-Factor-1, a Yeast Pheromone, and Its Analogue with Copper(II) Ions and Low-Molecular-Weight Ligands Yield Very Stable Complexes. Inorg Chem 55(16):7829-31 PMID:27476515
- Huberman LB and Murray AW (2014) A model for cell wall dissolution in mating yeast cells: polarized secretion and restricted diffusion of cell wall remodeling enzymes induces local dissolution. PLoS One 9(10):e109780 PMID:25329559
- Bener Aksam E, et al. (2013) Molecular characterization of Saccharomyces cerevisiae α-pheromone by mass spectrometry-based peptidomics. FEMS Yeast Res 13(3):350-3 PMID:23368790
- Gomes-Rezende JA, et al. (2012) Functionality of the Paracoccidioides mating α-pheromone-receptor system. PLoS One 7(10):e47033 PMID:23056569
- Murphy HA and Zeyl CW (2012) Prezygotic isolation between Saccharomyces cerevisiae and Saccharomyces paradoxus through differences in mating speed and germination timing. Evolution 66(4):1196-209 PMID:22486698
- Rogers DW, et al. (2012) Molecular quantification of Saccharomyces cerevisiae α-pheromone secretion. FEMS Yeast Res 12(6):668-74 PMID:22672638
- Wilmes A, et al. (2012) Chemical genetic profiling of the microtubule-targeting agent peloruside A in budding yeast Saccharomyces cerevisiae. Gene 497(2):140-6 PMID:22326528
- Forte GM, et al. (2011) N-terminal acetylation inhibits protein targeting to the endoplasmic reticulum. PLoS Biol 9(5):e1001073 PMID:21655302
- Umanah GK, et al. (2010) Identification of residue-to-residue contact between a peptide ligand and its G protein-coupled receptor using periodate-mediated dihydroxyphenylalanine cross-linking and mass spectrometry. J Biol Chem 285(50):39425-36 PMID:20923758
- Umanah GK, et al. (2009) Cross-linking of a DOPA-containing peptide ligand into its G protein-coupled receptor. Biochemistry 48(9):2033-44 PMID:19152328
- Watanabe R, et al. (2008) The presence of an ER exit signal determines the protein sorting upon ER exit in yeast. Biochem J 414(2):237-45 PMID:18462190
- Naider F, et al. (2007) Double-mutant cycle scanning of the interaction of a peptide ligand and its G protein-coupled receptor. Biochemistry 46(11):3476-81 PMID:17298081
- Nakatsukasa K, et al. (2004) Roles of O-mannosylation of aberrant proteins in reduction of the load for endoplasmic reticulum chaperones in yeast. J Biol Chem 279(48):49762-72 PMID:15377669
- Henry LK, et al. (2002) Identification of a contact region between the tridecapeptide alpha-factor mating pheromone of Saccharomyces cerevisiae and its G protein-coupled receptor by photoaffinity labeling. Biochemistry 41(19):6128-39 PMID:11994008
- Saskiawan I, et al. (2002) Chemo-enzymatic synthesis of the glycosylated alpha-mating factor of Saccharomyces cerevisiae and analysis of its biological activity. Arch Biochem Biophys 406(1):127-34 PMID:12234498
- Lee BK, et al. (2001) Identification of residues of the Saccharomyces cerevisiae G protein-coupled receptor contributing to alpha-factor pheromone binding. J Biol Chem 276(41):37950-61 PMID:11495900
- Liu S, et al. (2000) Position 13 analogs of the tridecapeptide mating pheromone from Saccharomyces cerevisiae: design of an iodinatable ligand for receptor binding. J Pept Res 56(1):24-34 PMID:10917454
- Abel MG, et al. (1998) Structure-function analysis of the Saccharomyces cerevisiae tridecapeptide pheromone using alanine-scanned analogs. J Pept Res 52(2):95-106 PMID:9727865
- Zhang YL, et al. (1997) Position one analogs of the Saccharomyces cerevisiae tridecapeptide pheromone. J Pept Res 50(5):319-28 PMID:9401915
- Houen G, et al. (1996) Structural requirements for alpha-mating factor activity. FEBS Lett 391(1-2):162-6 PMID:8706907
- Manfredi JP, et al. (1996) Yeast alpha mating factor structure-activity relationship derived from genetically selected peptide agonists and antagonists of Ste2p. Mol Cell Biol 16(9):4700-9 PMID:8756627
- Nacken V, et al. (1996) Probing the limits of expression levels by varying promoter strength and plasmid copy number in Saccharomyces cerevisiae. Gene 175(1-2):253-60 PMID:8917107
- Xue CB, et al. (1996) Probing the functional conformation of the tridecapeptide mating pheromone of Saccharomyces cerevisiae through study of disulfide-constrained analogs. Int J Pept Protein Res 47(3):131-41 PMID:8740961
- Kirk N and Piper PW (1994) Growth rate influences MF alpha 1 promoter activity in MAT alpha Saccharomyces cerevisiae. Appl Microbiol Biotechnol 42(2-3):340-5 PMID:7765775
- Levin Y, et al. (1993) Histidine2 of the alpha-factor of Saccharomyces cerevisiae is not essential for binding to its receptor or for biological activity. Biochemistry 32(32):8199-206 PMID:8394129
- Caplan S and Kurjan J (1991) Role of alpha-factor and the MF alpha 1 alpha-factor precursor in mating in yeast. Genetics 127(2):299-307 PMID:2004704
- Caplan S, et al. (1991) Glycosylation and structure of the yeast MF alpha 1 alpha-factor precursor is important for efficient transport through the secretory pathway. J Bacteriol 173(2):627-35 PMID:1987155
- Iida H, et al. (1990) Essential role for induced Ca2+ influx followed by [Ca2+]i rise in maintaining viability of yeast cells late in the mating pheromone response pathway. A study of [Ca2+]i in single Saccharomyces cerevisiae cells with imaging of fura-2. J Biol Chem 265(22):13391-9 PMID:2198292
- Nishizawa M, et al. (1990) Yeast Gal11 protein mediates the transcriptional activation signal of two different transacting factors, Gal4 and general regulatory factor I/repressor/activator site binding protein 1/translation upstream factor. Proc Natl Acad Sci U S A 87(14):5373-7 PMID:2196565
- Achstetter T (1989) Regulation of alpha-factor production in Saccharomyces cerevisiae: a-factor pheromone-induced expression of the MF alpha 1 and STE13 genes. Mol Cell Biol 9(10):4507-14 PMID:2685554
- Flessel MC, et al. (1989) The MF alpha 1 gene of Saccharomyces cerevisiae: genetic mapping and mutational analysis of promoter elements. Genetics 121(2):223-36 PMID:2659433
- Green R, et al. (1989) Misplacement of the amino-terminal positive charge in the prepro-alpha-factor signal peptide disrupts membrane translocation in vivo. J Biol Chem 264(5):2963-8 PMID:2563373
- Xue CB, et al. (1989) A covalently constrained congener of the Saccharomyces cerevisiae tridecapeptide mating pheromone is an agonist. J Biol Chem 264(32):19161-8 PMID:2681211
- Allison DS and Young ET (1988) Single-amino-acid substitutions within the signal sequence of yeast prepro-alpha-factor affect membrane translocation. Mol Cell Biol 8(5):1915-22 PMID:3290645
- Bourbonnais Y, et al. (1988) Secretion of somatostatin by Saccharomyces cerevisiae. Correct proteolytic processing of pro-alpha-factor-somatostatin hybrids requires the products of the KEX2 and STE13 genes. J Biol Chem 263(30):15342-7 PMID:2902090
- Inokuchi K, et al. (1988) Sequence-directed bends of DNA helix axis at the upstream activation sites of alpha-cell-specific genes in yeast. Nucleic Acids Res 16(14B):6693-711 PMID:3043374
- Jarvis EE, et al. (1988) Identification of a DNA segment that is necessary and sufficient for alpha-specific gene control in Saccharomyces cerevisiae: implications for regulation of alpha-specific and a-specific genes. Mol Cell Biol 8(1):309-20 PMID:3275872
- Raths SK, et al. (1988) Peptide analogues compete with the binding of alpha-factor to its receptor in Saccharomyces cerevisiae. J Biol Chem 263(33):17333-41 PMID:2846561
- Whiteway M, et al. (1988) Expression of MF alpha 1 in MATa cells supersensitive to alpha-factor leads to self-arrest. Mol Gen Genet 214(1):85-8 PMID:3067083
- Inokuchi K, et al. (1987) Identification of sequence elements that confer cell-type-specific control of MF alpha 1 expression in Saccharomyces cerevisiae. Mol Cell Biol 7(9):3185-93 PMID:2959859
- Rothblatt JA and Meyer DI (1986) Secretion in yeast: reconstitution of the translocation and glycosylation of alpha-factor and invertase in a homologous cell-free system. Cell 44(4):619-28 PMID:3512097
- Ammerer G, et al. (1985) Control of yeast alpha-specific genes: evidence for two blocks to expression in MATa/MAT alpha diploids. Proc Natl Acad Sci U S A 82(17):5855-9 PMID:3898074
- Baffi RA, et al. (1985) Structure-activity relationships in the dodecapeptide alpha-factor of Saccharomyces cerevisiae: position 6 analogues are poor inducers of agglutinability. Biochemistry 24(13):3332-7 PMID:3896309
- Kurjan J (1985) Alpha-factor structural gene mutations in Saccharomyces cerevisiae: effects on alpha-factor production and mating. Mol Cell Biol 5(4):787-96 PMID:3887136
- Brake AJ, et al. (1983) A functional prepro-alpha-factor gene in Saccharomyces yeasts can contain three, four, or five repeats of the mature pheromone sequence. Mol Cell Biol 3(8):1440-50 PMID:6353204
- Julius D, et al. (1983) Yeast alpha factor is processed from a larger precursor polypeptide: the essential role of a membrane-bound dipeptidyl aminopeptidase. Cell 32(3):839-52 PMID:6339075
- Orlean P, et al. (1983) Saccharomyces cerevisiae alpha-factor prevents formation of glycoproteins in a cells. FEBS Lett 158(2):247-51 PMID:6347714
- Singh A, et al. (1983) Saccharomyces cerevisiae contains two discrete genes coding for the alpha-factor pheromone. Nucleic Acids Res 11(12):4049-63 PMID:6306574
- Kurjan J and Herskowitz I (1982) Structure of a yeast pheromone gene (MF alpha): a putative alpha-factor precursor contains four tandem copies of mature alpha-factor. Cell 30(3):933-43 PMID:6754095
- Ciejek E, et al. (1977) Solid phase peptide synthesis of alpha-factor, a yeast mating pheromone. Biochem Biophys Res Commun 78(3):952-61 PMID:334181
- Shimoda C, et al. (1976) Mating reaction in Saccharomyces cerevisiae. IX. Regulation of sexual cell agglutinability of a type cells by a sex factor produced by alpha type cells. Arch Microbiol 108(1):27-33 PMID:776112
- Stötzler D and Duntze W (1976) Isolation and characterization of four related peptides exhibiting alpha factor activity from Saccharomyces cerevisiae. Eur J Biochem 65(1):257-62 PMID:776628
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Papers that show experimental evidence for the gene or describe homologs in other species, but
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Download References (.nbib)
- Banderas A, et al. (2025) Optogenetic control of pheromone gradients and mating behavior in budding yeast. Life Sci Alliance 8(6) PMID:40216553
- Pohl C, et al. (2025) LC-MS/MS quantification of bacterial and fungal signal peptides via direct injection: a case study of cross-kingdom communication. Anal Bioanal Chem 417(8):1677-1689 PMID:39903273
- Cole J and Schulman R (2024) Limiting the Broadcast Range of a Secreting Cell during Intercellular Signaling Using Protease-Mediated Degradation. ACS Synth Biol 13(7):2019-2028 PMID:38885472
- Heng YC, et al. (2024) Tunable cell differentiation via reprogrammed mating-type switching. Nat Commun 15(1):8163 PMID:39289346
- Fan C and Yuan J (2023) Reshaping the yeast galactose regulon via GPCR signaling cascade. Cell Rep Methods 3(12):100647 PMID:37989311
- Heltberg MS, et al. (2023) Coupled oscillator cooperativity as a control mechanism in chronobiology. Cell Syst 14(5):382-391.e5 PMID:37201507
- Parnell EJ, et al. (2021) Genetic analysis argues for a coactivator function for the Saccharomyces cerevisiae Tup1 corepressor. Genetics 219(2) PMID:34849878
- Tuong Vi DT, et al. (2021) Pbp1, the yeast ortholog of human Ataxin-2, functions in the cell growth on non-fermentable carbon sources. PLoS One 16(5):e0251456 PMID:33984024
- Shaw WM, et al. (2019) Engineering a Model Cell for Rational Tuning of GPCR Signaling. Cell 177(3):782-796.e27 PMID:30955892
- Billerbeck S, et al. (2018) A scalable peptide-GPCR language for engineering multicellular communication. Nat Commun 9(1):5057 PMID:30498215
- McClure AW, et al. (2018) Mating in wild yeast: delayed interest in sex after spore germination. Mol Biol Cell 29(26):3119-3127 PMID:30355051
- Urrios A, et al. (2018) Plug-and-Play Multicellular Circuits with Time-Dependent Dynamic Responses. ACS Synth Biol 7(4):1095-1104 PMID:29584406
- Hatch AJ, et al. (2017) Inositol phosphate multikinase dependent transcriptional control. Adv Biol Regul 64:9-19 PMID:28342784
- Rogers DW, et al. (2017) Diminishing Returns on Intragenic Repeat Number Expansion in the Production of Signaling Peptides. Mol Biol Evol 34(12):3176-3185 PMID:28961820
- Siu KH and Chen W (2017) Control of the Yeast Mating Pathway by Reconstitution of Functional α-Factor Using Split Intein-Catalyzed Reactions. ACS Synth Biol 6(8):1453-1460 PMID:28505429
- Vitale S, et al. (2017) Structure-Activity Relationship of α Mating Pheromone from the Fungal Pathogen Fusarium oxysporum. J Biol Chem 292(9):3591-3602 PMID:28100777
- Manfredi MA, et al. (2016) Specificity characterization of the α-mating factor hormone by Kex2 protease. Biochimie 131:149-158 PMID:27720750
- Mori A, et al. (2015) Signal peptide optimization tool for the secretion of recombinant protein from Saccharomyces cerevisiae. J Biosci Bioeng 120(5):518-25 PMID:25912446
- Rogers DW, et al. (2015) Experimental Evolution of Species Recognition. Curr Biol 25(13):1753-8 PMID:26073134
- Takenaka M, et al. (2015) The mapping of yeast's G-protein coupled receptor with an atomic force microscope. Nanoscale 7(11):4956-63 PMID:25690872
- Wolfe KH, et al. (2015) Clade- and species-specific features of genome evolution in the Saccharomycetaceae. FEMS Yeast Res 15(5):fov035 PMID:26066552
- Ventura AC, et al. (2014) Utilization of extracellular information before ligand-receptor binding reaches equilibrium expands and shifts the input dynamic range. Proc Natl Acad Sci U S A 111(37):E3860-9 PMID:25172920
- Youk H and Lim WA (2014) Secreting and sensing the same molecule allows cells to achieve versatile social behaviors. Science 343(6171):1242782 PMID:24503857
- Huberman LB and Murray AW (2013) Genetically engineered transvestites reveal novel mating genes in budding yeast. Genetics 195(4):1277-90 PMID:24121774
- Moore TI, et al. (2013) Yeast G-proteins mediate directional sensing and polarization behaviors in response to changes in pheromone gradient direction. Mol Biol Cell 24(4):521-34 PMID:23242998
- Vadhana AK, et al. (2013) Improved secretion of Candida antarctica lipase B with its native signal peptide in Pichia pastoris. Enzyme Microb Technol 52(3):177-83 PMID:23410929
- Hahne K, et al. (2012) Evaluation of substrate and inhibitor binding to yeast and human isoprenylcysteine carboxyl methyltransferases (Icmts) using biotinylated benzophenone-containing photoaffinity probes. Biochem Biophys Res Commun 423(1):98-103 PMID:22634004
- Hara K, et al. (2012) Membrane-displayed peptide ligand activates the pheromone response pathway in Saccharomyces cerevisiae. J Biochem 151(5):551-7 PMID:22406406
- Rodríguez Plaza JG, et al. (2012) Moonlighting peptides with emerging function. PLoS One 7(7):e40125 PMID:22808104
- Wang X, et al. (2011) Ste11p MEKK signals through HOG, mating, calcineurin and PKC pathways to regulate the FKS2 gene. BMC Mol Biol 12:51 PMID:22114773
- Andrews SS, et al. (2010) Detailed simulations of cell biology with Smoldyn 2.1. PLoS Comput Biol 6(3):e1000705 PMID:20300644
- Smith C and Greig D (2010) The cost of sexual signaling in yeast. Evolution 64(11):3114-22 PMID:20584074
- Zhang SQ, et al. (2010) A new multiple regression approach for the construction of genetic regulatory networks. Artif Intell Med 48(2-3):153-60 PMID:19963359
- Castillon GA, et al. (2009) Concentration of GPI-anchored proteins upon ER exit in yeast. Traffic 10(2):186-200 PMID:19054390
- Guzinska K, et al. (2009) Role of Plc1p in regulation of Mcm1p-dependent genes. FEMS Microbiol Lett 295(2):245-50 PMID:19459978
- Rogers DW and Greig D (2009) Experimental evolution of a sexually selected display in yeast. Proc Biol Sci 276(1656):543-9 PMID:18842545
- Shi C, et al. (2009) In vitro characterization of ligand-induced oligomerization of the S. cerevisiae G-protein coupled receptor, Ste2p. Biochim Biophys Acta 1790(1):1-7 PMID:18996443
- Singh I, et al. (2009) Stringent mating-type-regulated auxotrophy increases the accuracy of systematic genetic interaction screens with Saccharomyces cerevisiae mutant arrays. Genetics 181(1):289-300 PMID:18957706
- Tanaka H and Yi TM (2009) Reverse engineering a signaling network using alternative inputs. PLoS One 4(10):e7622 PMID:19898612
- Hausmann A, et al. (2008) Cellular and mitochondrial remodeling upon defects in iron-sulfur protein biogenesis. J Biol Chem 283(13):8318-30 PMID:18227070
- Zill OA and Rine J (2008) Interspecies variation reveals a conserved repressor of alpha-specific genes in Saccharomyces yeasts. Genes Dev 22(12):1704-16 PMID:18559484
- Ongay-Larios L, et al. (2007) Kluyveromyces lactis sexual pheromones. Gene structures and cellular responses to alpha-factor. FEMS Yeast Res 7(5):740-7 PMID:17506833
- Koufopanou V, et al. (2006) The spatial scale of genetic differentiation in a model organism: the wild yeast Saccharomyces paradoxus. Philos Trans R Soc Lond B Biol Sci 361(1475):1941-6 PMID:17028086
- Parker LL, et al. (2006) Control of the yeast cell cycle with a photocleavable alpha-factor analogue. Angew Chem Int Ed Engl 45(38):6322-5 PMID:16937420
- Richard GF and Dujon B (2006) Molecular evolution of minisatellites in hemiascomycetous yeasts. Mol Biol Evol 23(1):189-202 PMID:16177231
- Toshima JY, et al. (2006) Spatial dynamics of receptor-mediated endocytic trafficking in budding yeast revealed by using fluorescent alpha-factor derivatives. Proc Natl Acad Sci U S A 103(15):5793-8 PMID:16574772
- Yu H and Gerstein M (2006) Genomic analysis of the hierarchical structure of regulatory networks. Proc Natl Acad Sci U S A 103(40):14724-31 PMID:17003135
- Zhang NN, et al. (2006) Multiple signaling pathways regulate yeast cell death during the response to mating pheromones. Mol Biol Cell 17(8):3409-22 PMID:16738305
- Bowen S, et al. (2005) Patterns of polymorphism and divergence in stress-related yeast proteins. Yeast 22(8):659-68 PMID:16032761
- Bro C, et al. (2005) Improvement of galactose uptake in Saccharomyces cerevisiae through overexpression of phosphoglucomutase: example of transcript analysis as a tool in inverse metabolic engineering. Appl Environ Microbiol 71(11):6465-72 PMID:16269670
- Coppin E, et al. (2005) The function of the coding sequences for the putative pheromone precursors in Podospora anserina is restricted to fertilization. Eukaryot Cell 4(2):407-20 PMID:15701803
- Fabre E, et al. (2005) Comparative genomics in hemiascomycete yeasts: evolution of sex, silencing, and subtelomeres. Mol Biol Evol 22(4):856-73 PMID:15616141
- Verstrepen KJ, et al. (2005) Intragenic tandem repeats generate functional variability. Nat Genet 37(9):986-90 PMID:16086015
- Galgoczy DJ, et al. (2004) Genomic dissection of the cell-type-specification circuit in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 101(52):18069-74 PMID:15604142
- MacKay VL, et al. (2004) Gene expression analyzed by high-resolution state array analysis and quantitative proteomics: response of yeast to mating pheromone. Mol Cell Proteomics 3(5):478-89 PMID:14766929
- Kalkum M, et al. (2003) Detection of secreted peptides by using hypothesis-driven multistage mass spectrometry. Proc Natl Acad Sci U S A 100(5):2795-800 PMID:12591958
- Kodama T, et al. (2003) Molecular cloning and DNA analysis of a gene encoding alpha mating pheromone from the yeast Saccharomyces naganishii. Yeast 20(2):109-15 PMID:12518315
- Ding FX, et al. (2002) Study of the binding environment of alpha-factor in its G protein-coupled receptor using fluorescence spectroscopy. J Pept Res 60(1):65-74 PMID:12081627
- Wittke S, et al. (2002) Recognition of a subset of signal sequences by Ssh1p, a Sec61p-related protein in the membrane of endoplasmic reticulum of yeast Saccharomyces cerevisiae. Mol Biol Cell 13(7):2223-32 PMID:12134063
- Hauser NC, et al. (2001) Whole genome analysis of a wine yeast strain. Comp Funct Genomics 2(2):69-79 PMID:18628902
- Malpertuy A, et al. (2000) Genomic exploration of the hemiascomycetous yeasts: 19. Ascomycetes-specific genes. FEBS Lett 487(1):113-21 PMID:11152894
- Fujimura H (1999) Cell-cell recognition and pheromone response of the yeast Saccharomyces globosus. FEMS Microbiol Lett 173(1):63-8 PMID:10220882
- Siegel EG, et al. (1999) Characterization of novel peptide agonists of the alpha mating factor of Saccharomyces cerevisiae. Anal Biochem 275(1):109-15 PMID:10542115
- Kawamura-Watabe A and Tokunaga M (1997) Isolation and characterization of kar2-404 mutation in Saccharomyces cerevisiae. Biosci Biotechnol Biochem 61(7):1172-8 PMID:9255982
- Chen Q and Konopka JB (1996) Regulation of the G-protein-coupled alpha-factor pheromone receptor by phosphorylation. Mol Cell Biol 16(1):247-57 PMID:8524302
- Kozlov DG, et al. (1995) Host cell properties and external pH affect proinsulin production by Saccharomyces yeast. Yeast 11(8):713-24 PMID:7668041
- Tang G and Yang K (1995) Integration of glucoamylase gene from Aspergillus niger into Saccharomyces cerevisiae genome and its stable expression. Chin J Biotechnol 11(4):237-41 PMID:8739101
- Weydemann U, et al. (1995) High-level secretion of hirudin by Hansenula polymorpha--authentic processing of three different preprohirudins. Appl Microbiol Biotechnol 44(3-4):377-85 PMID:8597538
- Dubois E and Messenguy F (1994) Pleiotropic function of ArgRIIIp (Arg82p), one of the regulators of arginine metabolism in Saccharomyces cerevisiae. Role in expression of cell-type-specific genes. Mol Gen Genet 243(3):315-24 PMID:8043104
- Luo J, et al. (1994) Expression and secretion of alpha-amylase and glucoamylase in Saccharomyces cerevisiae. Chin J Biotechnol 10(4):241-8 PMID:7780020
- Mendoza-Vega O, et al. (1994) Production of recombinant hirudin by high cell density fed-batch cultivations of a Saccharomyces cerevisiae strain: physiological considerations during the bioprocess design. J Biotechnol 32(3):249-59 PMID:7764718
- Naumov GI, et al. (1994) Identification of new chromosomes of Saccharomyces bayanus using gene probes from S. cerevisiae. Hereditas 120(2):121-6 PMID:8083058
- Schwientek T and Ernst JF (1994) Efficient intra- and extracellular production of human beta-1,4-galactosyltransferase in Saccharomyces cerevisiae is mediated by yeast secretion leaders. Gene 145(2):299-303 PMID:8056347
- Harmsen MM, et al. (1993) Effect of a pmr 1 disruption and different signal sequences on the intracellular processing and secretion of Cyamopsis tetragonoloba alpha-galactosidase by Saccharomyces cerevisiae. Gene 125(2):115-23 PMID:8385051
- Lehman ED, et al. (1993) Expression, purification and characterization of multigram amounts of a recombinant hybrid HV1-HV2 hirudin variant expressed in Saccharomyces cerevisiae. Protein Expr Purif 4(3):247-55 PMID:8518563
- Ludwig DL, et al. (1993) High-level heterologous gene expression in Saccharomyces cerevisiae from a stable 2 microns plasmid system. Gene 132(1):33-40 PMID:8406040
- Achstetter T, et al. (1992) A new signal peptide useful for secretion of heterologous proteins from yeast and its application for synthesis of hirudin. Gene 110(1):25-31 PMID:1544574
- Chaudhuri B, et al. (1992) The pro-region of the yeast prepro-alpha-factor is essential for membrane translocation of human insulin-like growth factor 1 in vivo. Eur J Biochem 206(3):793-800 PMID:1606961
- Sumrada RA and Cooper TG (1992) The arginase (CAR1) gene is situated near MF alpha 1 on the right arm of chromosome XVI. Yeast 8(4):311-4 PMID:1514327
- Brutman AV, et al. (1991) [Preparation of Saccharomyces cerevisiae strains with regulated MFalpha1 promotor activity]. Mol Gen Mikrobiol Virusol 14-9 PMID:1787839
- Bush GL, et al. (1991) Secretion in yeast. Purification and in vitro translocation of chemical amounts of prepro-alpha-factor. J Biol Chem 266(21):13811-4 PMID:1856213
- Hofmann KJ and Schultz LD (1991) Mutations of the alpha-galactosidase signal peptide which greatly enhance secretion of heterologous proteins by yeast. Gene 101(1):105-11 PMID:1648007
- Inokuchi K and Nakayama A (1991) Lack of a requirement for strict rotational alignment among transcription factor binding sites in yeast. Nucleic Acids Res 19(11):3099-103 PMID:1905400
- Sakai A, et al. (1991) Enhanced secretion of human nerve growth factor from Saccharomyces cerevisiae using an advanced delta-integration system. Biotechnology (N Y) 9(12):1382-5 PMID:1369353
- Egel-Mitani M, et al. (1990) A novel aspartyl protease allowing KEX2-independent MF alpha propheromone processing in yeast. Yeast 6(2):127-37 PMID:2183521
- Laurent BC, et al. (1990) The SNF5 protein of Saccharomyces cerevisiae is a glutamine- and proline-rich transcriptional activator that affects expression of a broad spectrum of genes. Mol Cell Biol 10(11):5616-25 PMID:2233708
- Tsiomenko AB, et al. (1990) [The nature of N-terminal signal sequence determines the type of intracellular distribution and effectiveness of export of human growth hormone in Saccharomyces cerevisiae]. Mol Biol (Mosk) 24(4):1126-33 PMID:2250679
- Benitez J, et al. (1989) Secretion and glycosylation of Clostridium thermocellum endoglucanase A encoded by the celA gene in Saccharomyces cerevisiae. Yeast 5(4):299-306 PMID:2675490
- Das RC, et al. (1989) Alpha-factor leader sequence-directed transport of Escherichia coli beta-galactosidase in the secretory pathway of Saccharomyces cerevisiae. Mol Gen Genet 218(2):240-8 PMID:2506425
- Jelicks LA, et al. (1989) Interaction of the Saccharomyces cerevisiae alpha-factor with phospholipid vesicles as revealed by proton and phosphorus NMR. Biochemistry 28(10):4233-40 PMID:2669950
- Naider F, et al. (1989) Biologically significant conformation of the Saccharomyces cerevisiae alpha-factor. Biopolymers 28(1):487-97 PMID:2655735
- Passmore S, et al. (1989) A protein involved in minichromosome maintenance in yeast binds a transcriptional enhancer conserved in eukaryotes. Genes Dev 3(7):921-35 PMID:2673922
- Sanz P and Meyer DI (1989) Secretion in yeast: preprotein binding to a membrane receptor and ATP-dependent translocation are sequential and separable events in vitro. J Cell Biol 108(6):2101-6 PMID:2544601
- Hirschhorn JN and Winston F (1988) SPT3 is required for normal levels of a-factor and alpha-factor expression in Saccharomyces cerevisiae. Mol Cell Biol 8(2):822-7 PMID:3127692
- Jelicks LA, et al. (1988) A type II beta-turn in a flexible peptide: proton assignment and conformational analysis of the alpha-factor from Saccharomyces cerevisiae in solution. Biopolymers 27(3):431-49 PMID:3282563
- Kitada K and Hishinuma F (1988) Evidence for preferential multiplication of the internal unit in tandem repeats of the mating factor alpha genes in Saccharomyces yeasts. Curr Genet 13(1):1-5 PMID:2834101
- Miyajima I, et al. (1988) Suppressors of a gpa1 mutation cause sterility in Saccharomyces cerevisiae. Genetics 119(4):797-804 PMID:3137119
- Passmore S, et al. (1988) Saccharomyces cerevisiae protein involved in plasmid maintenance is necessary for mating of MAT alpha cells. J Mol Biol 204(3):593-606 PMID:3066908
- Waters MG, et al. (1988) Prepro-alpha-factor has a cleavable signal sequence. J Biol Chem 263(13):6209-14 PMID:3283123
- Moody AJ, et al. (1987) The secretion of glucagon by transformed yeast strains. FEBS Lett 212(2):302-6 PMID:3028866
- Sidhu RS and Bollon AP (1987) Analysis of alpha-factor secretion signals by fusing with acid phosphatase of yeast. Gene 54(2-3):175-84 PMID:2820840
- Tallon MA, et al. (1987) Synthesis and biological activity of amino terminus extended analogues of the alpha mating factor of Saccharomyces cerevisiae. Biochemistry 26(24):7767-74 PMID:3322407
- Tokunaga M, et al. (1987) A novel yeast secretion vector utilizing secretion signal of killer toxin encoded on the yeast linear DNA plasmid pGKL1. Biochem Biophys Res Commun 144(2):613-9 PMID:3555493
- Wakamatsu K, et al. (1987) Conformations of yeast alpha-mating factor and analog peptides as bound to phospholipid bilayer. Correlation of membrane-bound conformation with physiological activity. Eur J Biochem 163(2):331-8 PMID:3545832
- Barnes DA and Thorner J (1986) Genetic manipulation of Saccharomyces cerevisiae by use of the LYS2 gene. Mol Cell Biol 6(8):2828-38 PMID:3023949
- Ernst JF (1986) Improved secretion of heterologous proteins by Saccharomyces cerevisiae: effects of promoter substitution in alpha-factor fusions. DNA 5(6):483-91 PMID:3028738
- Wakamatsu K, et al. (1986) Nuclear-magnetic-resonance studies on the conformation of membrane-bound alpha-mating factor. Transferred nuclear Overhauser effect analysis. Eur J Biochem 154(3):607-15 PMID:3512267
- Fields S and Herskowitz I (1985) The yeast STE12 product is required for expression of two sets of cell-type specific genes. Cell 42(3):923-30 PMID:3931921
- Baffi RA, et al. (1984) Different structure-function relationships for alpha-factor-induced morphogenesis and agglutination in Saccharomyces cerevisiae. J Bacteriol 158(3):1152-6 PMID:6373738
- Higashijima T, et al. (1984) Nuclear-magnetic-resonance studies on the conformations of tridecapeptide alpha-mating factor from yeast Saccharomyces cerevisiae and analog peptides in aqueous solution. Conformation-activity relationship. Eur J Biochem 140(1):163-71 PMID:6323177
- Moore SA (1984) Yeast cells recover from mating pheromone alpha factor-induced division arrest by desensitization in the absence of alpha factor destruction. J Biol Chem 259(2):1004-10 PMID:6363399
- Ruíz T, et al. (1984) Influence of carbon catabolite repression on the G1 arrest of Saccharomyces cerevisiae MATa cells by alpha factor. J Gen Microbiol 130(2):337-42 PMID:6374021
- Singh A, et al. (1984) Synthesis, secretion and processing of alpha-factor-interferon fusion proteins in yeast. Nucleic Acids Res 12(23):8927-38 PMID:6083547
- Stetler GL and Thorner J (1984) Molecular cloning of hormone-responsive genes from the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 81(4):1144-8 PMID:6366798
- Emr SD, et al. (1983) An MF alpha 1-SUC2 (alpha-factor-invertase) gene fusion for study of protein localization and gene expression in yeast. Proc Natl Acad Sci U S A 80(23):7080-4 PMID:6359161
- Moore SA (1983) Comparison of dose-response curves for alpha factor-induced cell division arrest, agglutination, and projection formation of yeast cells. Implication for the mechanism of alpha factor action. J Biol Chem 258(22):13849-56 PMID:6358212
- Shenbagamurthi P, et al. (1983) Structure-activity relationships in the dodecapeptide alpha factor of Saccharomyces cerevisiae. Biochemistry 22(5):1298-304 PMID:6340736
- Tillmann U and Hahn H (1983) Antibodies against the alpha-factor pheromone of Saccharomyces cerevisiae. Z Naturforsch C Biosci 38(11-12):1069-71 PMID:6367248
- Finkelstein DB and McAlister L (1981) alpha-Factor-mediatd modification of a 32P-labeled protein by MATa cells of Saccharomyces cerevisiae. J Biol Chem 256(5):2561-6 PMID:7007388
- Khan SA, et al. (1981) Synthesis of the dodecapeptide-alpha mating factor of Saccharomyces cerevisiae. Int J Pept Protein Res 17(2):219-30 PMID:7014484
- Ciejek E and Thorner J (1979) Recovery of S. cerevisiae a cells from G1 arrest by alpha factor pheromone requires endopeptidase action. Cell 18(3):623-35 PMID:391400
- Doi S, et al. (1979) Induction of sexual cell agglutinability of A mating type cells by alpha-factor in Saccharomyces cerevisiae. Biochem Biophys Res Commun 91(3):849-53 PMID:393262
- Finkelstein DB and Strausberg S (1979) Metabolism of alpha-factor by a mating type cells of Saccharomyces cerevisiae. J Biol Chem 254(3):796-803 PMID:368060
- Lipke PN, et al. (1976) Morphogenic effects of alpha-factor on Saccharomyces cerevisiae a cells. J Bacteriol 127(1):610-8 PMID:776942
Reviews
No reviews curated.
Download References (.nbib)
- Merkaš M, et al. (2025) The MFα signal sequence in yeast-based protein secretion: challenges and innovations'. Appl Microbiol Biotechnol 109(1):138 PMID:40471355
- Thomas G, et al. (2022) The Path to Therapeutic Furin Inhibitors: From Yeast Pheromones to SARS-CoV-2. Int J Mol Sci 23(7) PMID:35408793
- Erpf PE and Fraser JA (2018) The Long History of the Diverse Roles of Short ORFs: sPEPs in Fungi. Proteomics 18(10):e1700219 PMID:29465163
- Hanson SJ and Wolfe KH (2017) An Evolutionary Perspective on Yeast Mating-Type Switching. Genetics 206(1):9-32 PMID:28476860
- Sridharan R, et al. (2014) Fluorescent approaches for understanding interactions of ligands with G protein coupled receptors. Biochim Biophys Acta 1838(1 Pt A):15-33 PMID:24055822
- Merlini L, et al. (2013) Mate and fuse: how yeast cells do it. Open Biol 3(3):130008 PMID:23466674
- Michaelis S and Barrowman J (2012) Biogenesis of the Saccharomyces cerevisiae pheromone a-factor, from yeast mating to human disease. Microbiol Mol Biol Rev 76(3):626-51 PMID:22933563
- Whiteway M (2011) Yeast mating: trying out new pickup lines. Curr Biol 21(16):R626-8 PMID:21855002
- Arkowitz RA (2009) Chemical gradients and chemotropism in yeast. Cold Spring Harb Perspect Biol 1(2):a001958 PMID:20066086
- Harashima S and Kaneko Y (2001) Application of the PHO5-gene-fusion technology to molecular genetics and biotechnology in yeast. J Biosci Bioeng 91(4):325-38 PMID:16233000
- Casselton LA and Olesnicky NS (1998) Molecular genetics of mating recognition in basidiomycete fungi. Microbiol Mol Biol Rev 62(1):55-70 PMID:9529887
- Gellissen G and Hollenberg CP (1997) Application of yeasts in gene expression studies: a comparison of Saccharomyces cerevisiae, Hansenula polymorpha and Kluyveromyces lactis -- a review. Gene 190(1):87-97 PMID:9185853
- Caldwell GA, et al. (1995) Fungal lipopeptide mating pheromones: a model system for the study of protein prenylation. Microbiol Rev 59(3):406-22 PMID:7565412
- Cross F, et al. (1988) Conjugation in Saccharomyces cerevisiae. Annu Rev Cell Biol 4:429-57 PMID:2848554
- Fuller RS, et al. (1988) Enzymes required for yeast prohormone processing. Annu Rev Physiol 50:345-62 PMID:3288097
Gene Ontology Literature
Paper(s) associated with one or more GO (Gene Ontology) terms in SGD for the specified gene.
No gene ontology literature curated.
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- Bossak K, et al. (2016) Interactions of α-Factor-1, a Yeast Pheromone, and Its Analogue with Copper(II) Ions and Low-Molecular-Weight Ligands Yield Very Stable Complexes. Inorg Chem 55(16):7829-31 PMID:27476515
- Kurjan J (1985) Alpha-factor structural gene mutations in Saccharomyces cerevisiae: effects on alpha-factor production and mating. Mol Cell Biol 5(4):787-96 PMID:3887136
- Singh A, et al. (1983) Saccharomyces cerevisiae contains two discrete genes coding for the alpha-factor pheromone. Nucleic Acids Res 11(12):4049-63 PMID:6306574
- Stötzler D and Duntze W (1976) Isolation and characterization of four related peptides exhibiting alpha factor activity from Saccharomyces cerevisiae. Eur J Biochem 65(1):257-62 PMID:776628
Phenotype Literature
Paper(s) associated with one or more pieces of classical phenotype evidence in SGD for the specified gene.
No phenotype literature curated.
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- Ruotolo R, et al. (2008) Membrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast. Genome Biol 9(4):R67 PMID:18394190
- Kurjan J (1985) Alpha-factor structural gene mutations in Saccharomyces cerevisiae: effects on alpha-factor production and mating. Mol Cell Biol 5(4):787-96 PMID:3887136
Interaction Literature
Paper(s) associated with evidence supporting a physical or genetic interaction between the
specified gene and another gene in SGD. Currently, all interaction evidence is obtained from
BioGRID.
No interaction literature curated.
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- Robeson L, et al. (2024) Characterization of the interaction between the Sec61 translocon complex and ppαF using optical tweezers. Protein Sci 33(6):e4996 PMID:38747383
- Sanders E, et al. (2020) Comprehensive Synthetic Genetic Array Analysis of Alleles That Interact with Mutation of the Saccharomyces cerevisiae RecQ Helicases Hrq1 and Sgs1. G3 (Bethesda) 10(12):4359-4368 PMID:33115720
- Espinosa-Cantú A, et al. (2018) Protein Moonlighting Revealed by Noncatalytic Phenotypes of Yeast Enzymes. Genetics 208(1):419-431 PMID:29127264
- Lapointe CP, et al. (2017) Architecture and dynamics of overlapped RNA regulatory networks. RNA 23(11):1636-1647 PMID:28768715
- Shulist K, et al. (2017) Interrogation of γ-tubulin alleles using high-resolution fitness measurements reveals a distinct cytoplasmic function in spindle alignment. Sci Rep 7(1):11398 PMID:28900268
- Costanzo M, et al. (2016) A global genetic interaction network maps a wiring diagram of cellular function. Science 353(6306) PMID:27708008
- Dubarry M, et al. (2015) Genetic Networks Required to Coordinate Chromosome Replication by DNA Polymerases α, δ, and ε in Saccharomyces cerevisiae. G3 (Bethesda) 5(10):2187-97 PMID:26297725
- Lapointe CP, et al. (2015) Protein-RNA networks revealed through covalent RNA marks. Nat Methods 12(12):1163-70 PMID:26524240
- Forte GM, et al. (2011) N-terminal acetylation inhibits protein targeting to the endoplasmic reticulum. PLoS Biol 9(5):e1001073 PMID:21655302
- Stirling PC, et al. (2011) The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components. PLoS Genet 7(4):e1002057 PMID:21552543
- Umanah GK, et al. (2010) Identification of residue-to-residue contact between a peptide ligand and its G protein-coupled receptor using periodate-mediated dihydroxyphenylalanine cross-linking and mass spectrometry. J Biol Chem 285(50):39425-36 PMID:20923758
- Batisse J, et al. (2009) Purification of nuclear poly(A)-binding protein Nab2 reveals association with the yeast transcriptome and a messenger ribonucleoprotein core structure. J Biol Chem 284(50):34911-7 PMID:19840948
- McClellan AJ, et al. (2007) Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches. Cell 131(1):121-35 PMID:17923092
- Raths SK, et al. (1988) Peptide analogues compete with the binding of alpha-factor to its receptor in Saccharomyces cerevisiae. J Biol Chem 263(33):17333-41 PMID:2846561
Regulation Literature
Paper(s) associated with one or more pieces of regulation evidence in SGD, as found on the
Regulation page.
No regulation literature curated.
Post-translational Modifications Literature
Paper(s) associated with one or more pieces of post-translational modifications evidence in SGD.
No post-translational modifications literature curated.
High-Throughput Literature
Paper(s) associated with one or more pieces of high-throughput evidence in SGD.
No high-throughput literature curated.
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- Mota MN, et al. (2024) Shared and more specific genetic determinants and pathways underlying yeast tolerance to acetic, butyric, and octanoic acids. Microb Cell Fact 23(1):71 PMID:38419072
- Choy JS, et al. (2013) Genome-wide haploinsufficiency screen reveals a novel role for γ-TuSC in spindle organization and genome stability. Mol Biol Cell 24(17):2753-63 PMID:23825022
- Michaillat L and Mayer A (2013) Identification of genes affecting vacuole membrane fragmentation in Saccharomyces cerevisiae. PLoS One 8(2):e54160 PMID:23383298
- Davey HM, et al. (2012) Genome-wide analysis of longevity in nutrient-deprived Saccharomyces cerevisiae reveals importance of recycling in maintaining cell viability. Environ Microbiol 14(5):1249-60 PMID:22356628
- Pir P, et al. (2012) The genetic control of growth rate: a systems biology study in yeast. BMC Syst Biol 6:4 PMID:22244311
- Uluisik I, et al. (2011) Boron stress activates the general amino acid control mechanism and inhibits protein synthesis. PLoS One 6(11):e27772 PMID:22114689
- Venters BJ, et al. (2011) A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces. Mol Cell 41(4):480-92 PMID:21329885
- Breslow DK, et al. (2008) A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods 5(8):711-8 PMID:18622397
- Cipollina C, et al. (2008) Saccharomyces cerevisiae SFP1: at the crossroads of central metabolism and ribosome biogenesis. Microbiology (Reading) 154(Pt 6):1686-1699 PMID:18524923
- Hu Z, et al. (2007) Genetic reconstruction of a functional transcriptional regulatory network. Nat Genet 39(5):683-7 PMID:17417638
- Brown JA, et al. (2006) Global analysis of gene function in yeast by quantitative phenotypic profiling. Mol Syst Biol 2:2006.0001 PMID:16738548
- Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91 PMID:12140549