Protein Help

KIP2 / YPL155C Protein

Protein abundance data, domains, shared domains with other proteins, protein sequence retrieval for various strains, sequence-based physico-chemical properties, protein modification sites, and external identifiers for the protein.


Feature Type
ORF , Verified

AlphaFold Protein Structure

AlphaFold, developed by DeepMind, is an AI program that accurately predicts protein structures from amino acid sequences, enabling visualization of protein conformations. The predicted structures can be accessed through the Protein Data Bank (PDB) and AlphaFold Protein Structure Database.


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Model Confidence

Very high
Confident
Low
Very low

Experimental Data

Contains experimentally-derived protein half-life data obtained using stable isotope labeling by amino acids (SILAC) coupled with mass spectrometry. This section also contains protein abundance data for both untreated and treated cells obtained from over 20 studies. These data have been normalized and converted to a common unit of molecules per cell.


Protein Half Life

No half-life data available for KIP2.

Protein Abundance

Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Abundance (molecules/cell)MediaTreatmentTreatment timeFold ChangeVisualizationStrain backgroundOriginal ReferenceReference
1666SDuntreatedconfocal microscopy evidenceS288CBreker M, et al. (2013)Ho B, et al. (2018)
1585SD2 mM 1,4-dithiothreitol2 hrconfocal microscopy evidenceS288CBreker M, et al. (2013)Ho B, et al. (2018)
1613SD1 mM hydrogen peroxide1 hrconfocal microscopy evidenceS288CBreker M, et al. (2013)Ho B, et al. (2018)
1148SD minus nitrogencellular response to nitrogen starvation15 hr0.69confocal microscopy evidenceS288CBreker M, et al. (2013)Ho B, et al. (2018)
1674SDuntreatedconfocal microscopy evidenceS288CChong YT, et al. (2015)Ho B, et al. (2018)
Showing 1 to 5 of 14 entries

Domains and Classification - S288C

Collection of computationally identified domains and motifs, as determined by InterProScan analysis; includes protein coordinates for the domain, a domain Description, a Source and corresponding accession ID, and the number of S. cerevisiae genes that share the same domain.


Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Gene Protein Coordinates Accession ID Description Source No. of Genes with Domain

Domain Locations

Visual representation of the locations of the domains within the protein, as listed in the Domains and Classification table. Each row displays the domain(s) derived from a different Source, with domains color-coded according to this Source.

Scroll over a domain to view its exact coordinates and its Description.

Shared Domains

This diagram displays domains (colored squares) shared between the given protein (yellow circle) and other proteins (gray circles); the domains are color-coded according to their source, as displayed in the Domain Locations table, above.

Reset

Click on a gene or domain name to go to its specific page within SGD; drag any of the gene or domain objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram.

Alleles

Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results.


Kip2-ΔN-ΔT | kip2-G374A | kip2-Δ | kip2-ΔN | kip2-ΔT | kip2-Δmotor

View all KIP2 alleles in SGD search

Sequence

Protein sequence for the given gene in S288C and other strains, when available. Use the pull-down menu under "Strain" to select the sequence for a specific strain. The displayed sequence can be downloaded in FASTA format as a .txt file. Amino acids displayed in blue represent modification sites. More detailed evidence for these modification sites is presented in the Post-translational Modifications table, located just below the protein sequence.


1 MIQKMSPSLR RPSTRSSSGS SNIPQSPSVR STSSFSNLTR NSIRSTSNSG SQSISASSTR
61 SNSPLRSVSA KSDPFLHPGR IRIRRSDSIN NNSRKNDTYT GSITVTIRPK PRSVGTSRDH
121 VGLKSPRYSQ PRSNSHHGSN TFVRDPWFIT NDKTIVHEEI GEFKFDHVFA SHCTNLEVYE
181 RTSKPMIDKL LMGFNATIFA YGMTGSGKTF TMSGNEQELG LIPLSVSYLF TNIMEQSMNG
241 DKKFDVIISY LEIYNERIYD LLESGLEESG SRISTPSRLY MSKSNSNGLG VELKIRDDSQ
301 YGVKVIGLTE RRCESSEELL RWIAVGDKSR KIGETDYNAR SSRSHAIVLI RLTSTNVKNG
361 TSRSSTLSLC DLAGSERATG QQERRKEGSF INKSLLALGT VISKLSADKM NSVGSNIPSP
421 SASGSSSSSG NATNNGTSPS NHIPYRDSKL TRLLQPALSG DSIVTTICTV DTRNDAAAET
481 MNTLRFASRA KNVALHVSKK SIISNGNNDG DKDRTIELLR RQLEEQRRMI SELKNRSNIG
541 EPLTKSSNES TYKDIKATGN DGDPNLALMR AENRVLKYKL ENCEKLLDKD VVDLQDSEIM
601 EIVEMLPFEV GTLLETKFQG LESQIRQYRK YTQKLEDKIM ALEKSGHTAM SLTGCDGTEV
661 IELQKMLERK DKMIEALQSA KRLRDRALKP LINTQQSPHP VVDNDK*

* Blue amino acids indicate modification sites. More information below.

Post-translational Modifications - S288C

Modification sites for the protein in the selected strain, based on the presence of a residue in the specific strain, as inferred from experimental evidence.

70 entries for 30 sites

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SiteModificationModifierReference
S6phosphorylated residueLeutert M, et al. (2023) PMID: 37845410
S16phosphorylated residueZhou X, et al. (2021) PMID: 33481703
S17phosphorylated residueMacGilvray ME, et al. (2020) PMID: 32597660
S18phosphorylated residueSwaney DL, et al. (2013) PMID: 23749301
S18phosphorylated residueZhou X, et al. (2021) PMID: 33481703
S18phosphorylated residueHolt LJ, et al. (2009) PMID: 19779198
S20phosphorylated residueLeutert M, et al. (2023) PMID: 37845410
S26phosphorylated residueZhou X, et al. (2021) PMID: 33481703
S26phosphorylated residueSwaney DL, et al. (2013) PMID: 23749301
S26phosphorylated residueLeutert M, et al. (2023) PMID: 37845410
Showing 1 to 10 of 70 entries

Sequence-Based Physico-chemical Properties - S288C

Calculated protein properties, including amino acid composition, length, coding region calculations, and atomic composition.

Amino Acid Composition

Sort table using the arrow to the right of a column header to sort by that column; download all properties as a .txt file using the "Download Properties" button.

Amino AcidFrequencyPercentage
A294.11
C60.85
D375.24
E446.23
F162.27
G436.09
H121.70
I466.52
K466.52
L628.78
M192.69
N456.37
P263.68
Q212.97
R547.65
S10214.45
T496.94
V314.39
W20.28
Y162.27

Physical Details

Length (a.a): 706
Molecular Weight (Da): 78398.5
Isoelectric Point (pl): 9.94
Formula: C3356H5521N1006O1102S25
Aliphatic Index: 74.79
Instability Index: 55.7

Coding Region Translation Calculations

Codon Bias: 0.07
Codon Adaptation Index: 0.12
Frequence of Optimal Codons: 0.46
Hydropathicity of Protein: -0.64
Aromaticity Score: 0.05

Extinction Coefficients at 280nm

ALL Cys residues appear as half cystines: 35215.0
NO Cys residues appear as half cystines: 34840.0

Atomic Composition

Sort table using the arrow to the right of a column header to sort by that column; download all properties as a .txt file using the "Download Properties" button.

Atom Frequency Percentage

Data not found or not available for  S288C

External Identifiers

List of external identifiers for the protein from various database sources.

23 entries for 10 sources


Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

External IDSource
AN8286AspGD
orf19.1747CGD
3012DIP
Z73511GenBank/EMBL/DDBJ
X96770GenBank/EMBL/DDBJ
6325102GenBank/EMBL/DDBJ
CAA78021.1GenBank/EMBL/DDBJ
CAA97860.1GenBank/EMBL/DDBJ
CAA65566.1GenBank/EMBL/DDBJ
Z11963GenBank/EMBL/DDBJ
Showing 1 to 10 of 23 entries

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