Sequence Help
RAD53 / YPL153C Sequence
Sequences and genome annotation information for Reference Strain S288C and a select set of
Alternative References.
- Aliases
-
LSD1
,
MEC2
11
,
SPK1
- Protein Product
-
serine/threonine/tyrosine protein kinase RAD53
- Feature Type
- ORF
, Verified
- Description
-
DNA damage response kinase; signal transduction pathway component required for DNA damage and replication checkpoints, promoting cell cycle arrest and DNA repair; role in initiation of DNA replication; inhibits gene gating through NPC protein phosphorylation, to promote fork stability; activates downstream kinase Dun1p; senses mtDNA depletion and mitochondrial ROS; relocalizes to cytosol under hypoxia; contains two FHA domains; human homolog CHEK2 implicated in breast cancer complements the null
2
3
4
5
6
7
8
9
10
- EC Number
-
2.7.12.1