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RAD53 / YPL153C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.


Aliases
LSD1 , MEC2 11 , SPK1 32
Protein Product
serine/threonine/tyrosine protein kinase RAD53
Feature Type
ORF , Verified
Description
DNA damage response kinase; signal transduction pathway component required for DNA damage and replication checkpoints, promoting cell cycle arrest and DNA repair; role in initiation of DNA replication; inhibits gene gating through NPC protein phosphorylation, to promote fork stability; activates downstream kinase Dun1p; senses mtDNA depletion and mitochondrial ROS; relocalizes to cytosol under hypoxia; contains two FHA domains; human homolog CHEK2 implicated in breast cancer complements the null 2 3 4 5 6 7 8 9 10
EC Number
2.7.12.1

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