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ATG5 / YPL149W Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.


Aliases
APG5 2
Feature Type
ORF , Verified
Description
Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjugate enhances E2 activity of Atg3 by rearranging its catalytic site, also forms a complex with Atg16p; the Atg5-Atg12/Atg16 complex binds to membranes and is essential for autophagosome formation; also involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner 2 3 4 5 6 7 8

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