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VPS30 / YPL120W Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.


Aliases
ATG6 11 , APG6 4 , VPT30 2
Protein Product
beclin 1
Feature Type
ORF , Verified
Description
Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy, Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; C-terminus has novel globular fold essential for autophagy through the targeting of the PI3-kinase complex I to the pre-autophagosomal structure; ortholog of higher eukaryote gene Beclin 1; human BECN1 can complement yeast null mutant 3 4 5 6 7 8

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