GRX5 / YPL059W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

GRX5/YPL059W is a non-essential gene in reference strain S288C. Null mutants are viable and demonstrate a broad array of phenotypic defects, including decreased oxidative stress resistance, reduced replicative and chronological lifespans, impaired respiratory metabolism, slower vegetative growth, diminished desiccation resistance, and lower starvation resistance. These defects indicate that while GRX5 is essential for optimal cell function and stress response, it is not strictly required for survival under standard conditions. Overexpression of GRX5 enhances desiccation resistance, suggesting that increased levels of GRX5 can provide protection against dry conditions, although it also leads to decreased resistance to hyperosmotic stress. These findings highlight the pivotal role of GRX5 in balancing oxidative stress and overall cellular health, impacting essential processes such as growth, metabolism, and survival under various stress conditions.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources