Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
19 entries for 15 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| biofilm formation: decreased | systematic mutation set | null Allele: vtc3-Δ | Sigma1278b | Scherz K, et al. (2014) PMID:25009170 | ||
| chemical compound accumulation: decreased | classical genetics | null Allele: vtc3-Δ | Other | polyphosphate | Treatment: polyphosphate overplus (phosphate starvation followed by high phosphate treatment) Details: significant reduction in polyphosphate levels (14% of wildtype) | Ogawa N, et al. (2000) PMID:11102525 |
| chemical compound accumulation: decreased | classical genetics | reduction of function Allele: vtc3- K130A/K133A within SPX domain | S288C | polyphosphate | Wild R, et al. (2016) PMID:27080106 | |
| chemical compound accumulation: decreased | classical genetics | reduction of function Allele: vtc3- K133A/K136A within SPX domain | S288C | polyphosphate | Wild R, et al. (2016) PMID:27080106 | |
| chitin deposition: increased | systematic mutation set | null Allele: vtc3-Δ | S288C | Details: increased cell wall chitin using a five cycle reiterative enrichment strategy and FACS sorting of cells labelled with either GFP-tagged chitinase or Calcofluor white | Chuene LT, et al. (2024) PMID:39270658 | |
| chitin deposition: increased | classical genetics | null Allele: vtc3-Δ | S288C | Details: increased cell wall chitin using both flow cytometry with Calcofluor white staining and GFP chitinase | Chuene LT, et al. (2024) PMID:39270658 | |
| colony appearance: abnormal | systematic mutation set | null Allele: vtc3-Δ | Sigma1278b | Media: YP sucrose plates Details: little bit wrinkly in the middle compared to the overall wrinkled appearance of wt colonies | Voordeckers K, et al. (2012) PMID:22882838 | |
| competitive fitness: increased | competitive growth fitness profiling using complete deletion alleles | null Allele: vtc3-Δ | S288C | Media: minimal medium Details: Relative fitness score: 1.011 | Breslow DK, et al. (2008) PMID:18622397 | |
| metal resistance: decreased | systematic mutation set | overexpression | S288C | 20 mM manganese(II) chloride | Details: exacerbates toxicity | Chakrabortee S, et al. (2016) PMID:27693355 |
| metal resistance: increased | systematic mutation set | null Allele: vtc3-Δ | S288C | 25 mM manganese(2+) | Chesi A, et al. (2012) PMID:22457822 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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