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ALA1 / YOR335C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

CDC64 8
Protein Product
alanine--tRNA ligase
Feature Type
ORF , Verified
Cytoplasmic and mitochondrial alanyl-tRNA synthetase; required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog AARS; mutations in human homolog AARS are associated with autoimmune disease polymyositis/dermatomyositis and with hereditary peripheral neuropathy, Charcot-Marie-Tooth (CMT) disease 1 2 3 4
EC Number