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LAS17 / YOR181W Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

BEE1 2
Protein Product
actin-binding protein LAS17
Feature Type
ORF , Verified
Actin assembly factor; C-terminal WCA domain activates Arp2/3 complex-mediated nucleation of branched actin filaments, polyproline domain nucleates actin filaments independent of Arp2/3; mutants are defective in endocytosis, bud site selection, cytokinesis; human homolog WAS (Wiskott-Aldrich Syndrome) implicated in severe immunodeficiency; human WAS complements yeast null mutant, but only in presence of WIPF1, which mediates localization of WAS to cortical patches 1 2 3 4 5 6