Phenotype Help

TIR2 / YOR010C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.



Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

14 entries for 13 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
acid pH resistance: decreased
systematic mutation setnull
Allele: tir2-Δ
S288C20 mM propionic acidMira NP, et al. (2009) PMID:19220866
chemical compound accumulation: abnormal
systematic mutation setnull
Allele: tir2-Δ
S288C alpha-amino acidDetails: Significantly altered free amino acid profile (X^2- test p < 0.01)
Mülleder M, et al. (2016) PMID:27693354
competitive fitness: increased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: tir2-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 1.03
Breslow DK, et al. (2008) PMID:18622397
fermentative metabolism: increased rate
classical geneticsoverexpressionOtherTemperature: permissive temperature, 25 °C
Chiva R, et al. (2012) PMID:22835029
fermentative metabolism: increased rate
classical geneticsoverexpressionOtherTemperature: reduced temperature, 13 °C
Chiva R, et al. (2012) PMID:22835029
haploinsufficient
heterozygous diploid, competitive growth

genome-wide fitness profiling

null
Allele: tir2-Δ
S288CMedia: turbidostat growth in FPM medium
Details: Relative growth score: -0.0064
Pir P, et al. (2012) PMID:22244311
killer toxin resistance: increased
systematic mutation setnull
Allele: tir2-Δ
S288CDetails: K2
Servienė E, et al. (2012) PMID:23227207
resistance to chemicals: decreased
systematic mutation setnull
Allele: tir2-Δ
S288C nickel(2+)Bishop AL, et al. (2007) PMID:17176259
resistance to chemicals: increased
systematic mutation setnull
Allele: tir2-Δ
S288C60 uM edelfosineCuesta-Marbán Á, et al. (2013) PMID:23335509
starvation resistance: decreased
heterozygous diploid, competitive growth

pooled mutant strains were subjected to low nutrient stress, then dead cells were separated and their mutations identified

null
Allele: tir2-Δ
S288CDavey HM, et al. (2012) PMID:22356628
Showing 1 to 10 of 14 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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