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SGT2 / YOR007C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.


Feature Type
ORF , Verified
Description
Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; similar to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress 2 3 4 5 6 7

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