Phenotype Help

RIB4 / YOL143C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.



Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

47 entries for 20 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
acid pH resistance: decreased
systematic mutation setnull
Allele: rib4-Δ
S288C20 mM propionic acidMira NP, et al. (2009) PMID:19220866
alkaline pH resistance: decreased
systematic mutation setnull
Allele: rib4-Δ
S288C60 mM calcium dichlorideMedia: alkaline conditions, pH 7.5
Media: YPD
Details: growth defects at pH 7.5 in 60 mM calcium chloride - vma phenotype
Sambade M, et al. (2005) PMID:15937126
alkaline pH resistance: decreased
systematic mutation setnull
Allele: rib4-Δ
S288CMedia: pH 6.8 to pH 7.5, in steps of 0.1-0.2 pH units
Serrano R, et al. (2004) PMID:14993228
anaerobic growth: decreased
systematic mutation setnull
Allele: rib4-Δ
S288CDetails: anaerobic growth on media supplemented with either ergosterol or cholesterol is reduced
Reiner S, et al. (2006) PMID:16251356
auxotrophy
classical geneticsunspecifiedS288C riboflavinOltmanns O, et al. (1969) PMID:5366000
budding pattern: abnormal
homozygous diploid, systematic mutation setnull
Allele: rib4-Δ
S288CDetails: >50% of cells exhibited random budding pattern
Ni L and Snyder M (2001) PMID:11452010
cell shape: abnormal
homozygous diploid, large-scale surveynull
Allele: rib4-Δ
S288CDetails: round cell shape; moderate defect
Ni L and Snyder M (2001) PMID:11452010
chemical compound accumulation: increased
classical geneticsunspecifiedOther 6,7-dimethyl-8-(1-D-ribityl)lumazineDetails: indicative of the riboflavin biosynthetic intermediate 5-amino-2,6-dihydroxy-4-ribitylaminopyrimidine; since the intermediate was labile it was reacted with diacetyl, yielding 6,7-dimethyl-8-ribityllumazine
Oltmanns O, et al. (1969) PMID:5366000
chronological lifespan: decreased
systematic mutation setnull
Allele: rib4-Δ
S288CMarek A and Korona R (2013) PMID:24151994
chronological lifespan: decreased
systematic mutation set null
Allele: rib4-Δ
S288CCampos SE, et al. (2018) PMID:29575540
Showing 1 to 10 of 47 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


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