AboutBlogDownloadExploreHelpGet Data
Protein Help

ARG8 / YOL140W Protein

Protein abundance data, domains, shared domains with other proteins, protein sequence retrieval for various strains, sequence-based physico-chemical properties, protein modification sites, and external identifiers for the protein.

Protein Product
acetylornithine transaminase
Feature Type
ORF , Verified
EC Number
2.6.1.11

AlphaFold Protein Structure

AlphaFold, developed by DeepMind, is an AI program that accurately predicts protein structures from amino acid sequences, enabling visualization of protein conformations. The predicted structures can be accessed through the Protein Data Bank (PDB) and AlphaFold Protein Structure Database.

Parsing response... [0/0]

Model Confidence

Very high
Confident
Low
Very low

Experimental Data

Contains experimentally-derived protein half-life data obtained using stable isotope labeling by amino acids (SILAC) coupled with mass spectrometry. This section also contains protein abundance data for both untreated and treated cells obtained from over 20 studies. These data have been normalized and converted to a common unit of molecules per cell.

Protein Half Life

Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

ExperimentResultReference
half-life>= 100 hrChristiano R, et al. (2014)

Protein Abundance

Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Abundance (molecules/cell)MediaTreatmentTreatment timeFold ChangeVisualizationStrain backgroundOriginal ReferenceReference
25574SDuntreatedconfocal microscopy evidenceS288CBreker M, et al. (2013)Ho B, et al. (2018)
12045SD2 mM 1,4-dithiothreitol2 hrconfocal microscopy evidenceS288CBreker M, et al. (2013)Ho B, et al. (2018)
17508SD1 mM hydrogen peroxide1 hrconfocal microscopy evidenceS288CBreker M, et al. (2013)Ho B, et al. (2018)
6656SD minus nitrogencellular response to nitrogen starvation15 hrconfocal microscopy evidenceS288CBreker M, et al. (2013)Ho B, et al. (2018)
18532SDuntreatedconfocal microscopy evidenceS288CChong YT, et al. (2015)Ho B, et al. (2018)
Showing 1 to 5 of 26 entries

Domains and Classification - S288C

Collection of computationally identified domains and motifs, as determined by InterProScan analysis; includes protein coordinates for the domain, a domain Description, a Source and corresponding accession ID, and the number of S. cerevisiae genes that share the same domain.

Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Gene Protein Coordinates Accession ID Description Source No. of Genes with Domain

Domain Locations

Visual representation of the locations of the domains within the protein, as listed in the Domains and Classification table. Each row displays the domain(s) derived from a different Source, with domains color-coded according to this Source.

Scroll over a domain to view its exact coordinates and its Description.

Shared Domains

This diagram displays domains (colored squares) shared between the given protein (yellow circle) and other proteins (gray circles); the domains are color-coded according to their source, as displayed in the Domain Locations table, above.

Reset

Click on a gene or domain name to go to its specific page within SGD; drag any of the gene or domain objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram.

Alleles

Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results.

arg8-Δ

View all ARG8 alleles in SGD search

Sequence

Protein sequence for the given gene in S288C and other strains, when available. Use the pull-down menu under "Strain" to select the sequence for a specific strain. The displayed sequence can be downloaded in FASTA format as a .txt file. Amino acids displayed in blue represent modification sites. More detailed evidence for these modification sites is presented in the Post-translational Modifications table, located just below the protein sequence. 

  1 MFKRYLSSTS SRRFTSILEE KAFQVTTYSR PEDLCITRGK NAKLYDDVNG KEYIDFTAGI 
 61 AVTALGHANP KVAEILHHQA NKLVHSSNLY FTKECLDLSE KIVEKTKQFG GQHDASRVFL 
121 CNSGTEANEA ALKFAKKHGI MKNPSKQGIV AFENSFHGRT MGALSVTWNS KYRTPFGDLV 
181 PHVSFLNLND EMTKLQSYIE TKKDEIAGLI VEPIQGEGGV FPVEVEKLTG LKKICQDNDV 
241 IVIHDEIQCG LGRSGKLWAH AYLPSEAHPD IFTSAKALGN GFPIAATIVN EKVNNALRVG 
301 DHGTTYGGNP LACSVSNYVL DTIADEAFLK QVSKKSDILQ KRLREIQAKY PNQIKTIRGK 
361 GLMLGAEFVE PPTEVIKKAR ELGLLIITAG KSTVRFVPAL TIEDELIEEG MDAFEKAIEA 
421 VYA*

* Blue amino acids indicate modification sites. More information below.

Post-translational Modifications - S288C

Modification sites for the protein in the selected strain, based on the presence of a residue in the specific strain, as inferred from experimental evidence.

5 entries for 5 sites

Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

SiteModificationModifierReference
S145phosphorylated residueLeutert M, et al. (2023) PMID: 37845410
S155phosphorylated residueLeutert M, et al. (2023) PMID: 37845410
S184phosphorylated residueLanz MC, et al. (2021) PMID: 33491328
T373phosphorylated residueLeutert M, et al. (2023) PMID: 37845410
T401phosphorylated residueLeutert M, et al. (2023) PMID: 37845410
Showing 1 to 5 of 5 entries

Sequence-Based Physico-chemical Properties - S288C

Calculated protein properties, including amino acid composition, length, coding region calculations, and atomic composition.

Amino Acid Composition

Sort table using the arrow to the right of a column header to sort by that column; download all properties as a .txt file using the "Download Properties" button.

Amino AcidFrequencyPercentage
A368.51
C61.42
D194.49
E337.80
F194.49
G327.57
H122.84
I307.09
K378.75
L378.75
M61.42
N204.73
P153.55
Q133.07
R153.55
S255.91
T266.15
V286.62
W20.47
Y122.84

Physical Details

Length (a.a): 423
Molecular Weight (Da): 46681.9
Isoelectric Point (pl): 7.62
Formula: C2087H3320N564O624S12
Aliphatic Index: 86.06
Instability Index: 32.33

Coding Region Translation Calculations

Codon Bias: 0.2
Codon Adaptation Index: 0.21
Frequence of Optimal Codons: 0.55
Hydropathicity of Protein: -0.24
Aromaticity Score: 0.08

Extinction Coefficients at 280nm

ALL Cys residues appear as half cystines: 29255.0
NO Cys residues appear as half cystines: 28880.0

Atomic Composition

Sort table using the arrow to the right of a column header to sort by that column; download all properties as a .txt file using the "Download Properties" button.

Atom Frequency Percentage

Data not found or not available for  S288C

External Identifiers

List of external identifiers for the protein from various database sources.

24 entries for 11 sources

Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

External IDSource
AN1150AspGD
orf19.3770CGD
2623DIP
2.6.1.11ExPASy
6324432GenBank/EMBL/DDBJ
X84036GenBank/EMBL/DDBJ
CAA99161.1GenBank/EMBL/DDBJ
CAA58853.1GenBank/EMBL/DDBJ
AAA34436.1GenBank/EMBL/DDBJ
M32795GenBank/EMBL/DDBJ
Showing 1 to 10 of 24 entries

Resources

Homologs

AGD | AnalogYeast | AspGD | BLASTP at NCBI | CGD | FungiDB | PhylomeDB | PomBase | YGOB | YOGY

Protein Databases

AlphaFold Protein Structure | GPMDB | ModelArchive | Pfam domains | SUPERFAMILY | TopologYeast | UniProtKB

Localization

CYCLoPs | dHITS | LoQAtE | YeastGFP | YeastRC Public Images | YeastRGB | YPL+

Post-translational Modifications

CoSMoS.c. | PhosphoGRID | PhosphoPep