Phenotype Help

TPT1 / YOL102C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.



Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

8 entries for 5 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
competitive fitness: decreased
competitive growth

fitness profiling of essential genes using hypomorphic DAmP alleles

reduction of functionS288CMedia: minimal medium
Details: Relative fitness score: 0.928
Breslow DK, et al. (2008) PMID:18622397
inviable
systematic mutation setnull
Allele: tpt1-Δ
S288CGiaever G, et al. (2002) PMID:12140549
inviable
classical geneticsnull
Allele: tpt1-Δ
S288CSéron K, et al. (1999) PMID:10028187
resistance to chemicals: decreased
systematic mutation setconditional
Allele: tpt1-5001
S288C10 ug/mL micafunginForster DT, et al. (2022) PMID:36192463
resistance to chemicals: increased
large-scale survey

variomic library screening of ~10,000 alleles for each gene

unspecifiedS288C100 ng/ml cycloheximideHuang Z, et al. (2013) PMID:23416056
resistance to chemicals: increased
systematic mutation setconditional
Allele: tpt1-5001
S288C2 ug/mL camptothecinForster DT, et al. (2022) PMID:36192463
resistance to chemicals: increased
systematic mutation setconditional
Allele: tpt1-5001
S288C50 ug/mL acivicinForster DT, et al. (2022) PMID:36192463
toxin resistance: decreased
systematic mutation set conditionalS288CTemperature: permissive temperature, 22 °C
Treatment: Aβ42
Details: decreased resistance to the toxicity of Aβ42, a 42 AA aggregate prone proteolytic product of the human amyloid precursor protein (APP)
Chen X, et al. (2020) PMID:32054832
Showing 1 to 8 of 8 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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