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DIS3 / YOL021C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

MTR17 24 , RRP44 12
Protein Product
exosome catalytic subunit DIS3
Feature Type
ORF , Verified
Exosome core complex catalytic subunit; has both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; role in degradation of tRNAs; similar to E. coli RNase R and to human DIS3, which partially complements dis3-81 heat sensitivity; mutations in Dis3p analogous to human mutations implicated in multiple myeloma impair exosome function; protein abundance increases under to DNA replication stress 2 3 4 5 6 7 8 9 10 11