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HRD1 / YOL013C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

DER3 2
Protein Product
E3 ubiquitin-protein ligase HRD1
Feature Type
ORF , Verified
Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) of misfolded proteins; upon autoubiquitination triggers retrotranslocation of misfolded proteins to cytosol for degradation; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon 1 2 3 4 5 6 7 8 9
EC Number