Sequence Help
TOP1 / YOL006C Sequence
Sequences and genome annotation information for Reference Strain S288C and a select set of
Alternative References.
- Aliases
-
MAK1
1
,
MAK17
14
- Protein Product
-
DNA topoisomerase 1
- Feature Type
- ORF
, Verified
- Description
-
Topoisomerase I; nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; role in processing ribonucleoside monophosphates in genomic DNA into irreversible single-strand breaks; enzymatic activity and interaction with Nsr1p are negatively regulated by polyphosphorylation
1
2
3
4
5
- EC Number
-
5.6.2.1