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TOP1 / YOL006C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

MAK1 1 , MAK17 15
Protein Product
DNA topoisomerase 1
Feature Type
ORF , Verified
Topoisomerase I; nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; role in processing ribonucleoside monophosphates in genomic DNA into irreversible single-strand breaks; enzymatic activity and interaction with Nsr1p are negatively regulated by polyphosphorylation 1 2 3 4 5 6
EC Number