Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
25 entries for 13 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| cell cycle progression in G1 phase: abnormal | large-scale survey | repressible | S288C | Details: accumulation of cells with a 1C DNA content indicative of a G1 arrest or delay | Yu L, et al. (2006) PMID:16943325 | |
| cell shape: abnormal | classical genetics | conditional Allele: emw1-1 L10S, V422G, Y435C | S288C | Temperature: permissive temperature, 25 °C Details: mutant cells are rounder at both 25 deg C and 37 deg C | Sipling T, et al. (2011) PMID:21273246 | |
| cell size: increased | classical genetics | conditional Allele: emw1-1 L10S, V422G, Y435C | S288C | Temperature: permissive temperature, 25 °C Details: increased size and 25 deg C and 37 deg C | Sipling T, et al. (2011) PMID:21273246 | |
| chitin deposition: increased | classical genetics | conditional Allele: emw1-1 L10S, V422G, Y435C | S288C | Temperature: permissive temperature, 25 °C Details: excess and aberrant chitin deposition at both 25 deg C and 37 deg C | Sipling T, et al. (2011) PMID:21273246 | |
| competitive fitness: decreased | competitive growth fitness profiling of essential genes using hypomorphic DAmP alleles | reduction of function | S288C | Media: minimal medium Details: Relative fitness score: 0.970 | Breslow DK, et al. (2008) PMID:18622397 | |
| growth in exponential phase: decreased rate | classical genetics | conditional Allele: emw1-1 L10S, V422G, Y435C | S288C | Temperature: permissive temperature, 25 °C Details: doubling time increased from 90 min in wt to 270 min in the mutant | Sipling T, et al. (2011) PMID:21273246 | |
| haploinsufficient | heterozygous diploid, competitive growth genome-wide fitness profiling | null Allele: emw1-Δ | S288C | Media: turbidostat growth in FPM medium Details: Relative growth score: -0.0033 | Pir P, et al. (2012) PMID:22244311 | |
| haploinsufficient | heterozygous diploid, competitive growth | null Allele: emw1-Δ | S288C | Treatment: conditions that mimic Phase II of a batch fermentation, equivalent to ~22 hours after inoculation of a batch fermentation | Novo M, et al. (2013) PMID:24040173 | |
| haploinsufficient | heterozygous diploid, systematic mutation set | null Allele: emw1-Δ | S288C | Ohnuki S and Ohya Y (2018) PMID:29768403 | ||
| heat sensitivity: increased | large-scale survey | conditional Allele: emw1-ts | S288C | Temperature: elevated temperature, 37 °C Details: no growth | Ben-Aroya S, et al. (2008) PMID:18439903 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
Addgene Plasmids | DNASU Plasmids | PlasmID | Thermo Scientific | YGRC
dHITS | FitDB | HIPHOP Chemogenomics | HIP HOP Profiles | PROPHECY | SCMD | ScreenTroll | TheCellVision | Yeast Phenome