Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
57 entries for 18 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| cell cycle progression in S phase: increased duration | classical genetics | null Allele: tof1-Δ | W303 | Tourrière H, et al. (2005) PMID:16137625 | ||
| chromosome/plasmid maintenance: abnormal | homozygous diploid | null Allele: tof1-Δ | S288C | Assay: diploid bimater (BiM) assay Details: increased frequency of mitotic chromosome loss | Daniel JA, et al. (2006) PMID:16157669 | |
| chromosome/plasmid maintenance: abnormal | homozygous diploid | null Allele: tof1-Δ | S288C | Assay: diploid bimater (BiM) assay Details: indicative of chromosome instability (CIN); high confidence set; >= 5-fold increase over wildtype | Yuen KW, et al. (2007) PMID:17360454 | |
| chromosome/plasmid maintenance: abnormal | classical genetics | null Allele: tof1-Δ | S288C | Assay: a-like faker (ALF) assay Details: indicative of chromosome instability (CIN); high confidence set; 2- to 80-fold increase relative to wildtype | Yuen KW, et al. (2007) PMID:17360454 | |
| chromosome/plasmid maintenance: decreased | classical genetics | null Allele: tof1-Δ | Other | 15 ug/ml nocodazole | Phase: G2/M phase Details: precocious sister chromatid separation in ~13% of mitotic cells | Boginya A, et al. (2019) PMID:31222142 |
| chromosome/plasmid maintenance: decreased | classical genetics | null Allele: tof1-Δ | S288C | Details: 113-fold increase in chromosome instability (CIN) relative to wt using a single-cell quantitative chromosome transmission fidelity (qCTF) assay that detects the loss of an ectopic chromosomal fragment of chrIII; CIN rate is suppressed by a helicase-dead mutant and by 32% when RRM3 is deleted | Gordon MR, et al. (2023) PMID:36350688 | |
| colony sectoring: increased | classical genetics | null Allele: tof1-Δ | S288C | Assay: chromosome transmission fidelity (CTF) assay Details: indicative of chromosome instability (CIN); high confidence set; severe sectoring phenotype | Yuen KW, et al. (2007) PMID:17360454 | |
| competitive fitness: decreased | competitive growth fitness profiling using complete deletion alleles | null Allele: tof1-Δ | S288C | Media: minimal medium Details: Relative fitness score: 0.955 | Breslow DK, et al. (2008) PMID:18622397 | |
| competitive fitness: decreased | systematic mutation set | null Allele: tof1-Δ | S288C | Media: rich medium (YPD) w/6% ethanol, ETH | Qian W, et al. (2012) PMID:23103169 | |
| competitive fitness: decreased | systematic mutation set | null Allele: tof1-Δ | S288C | Media: YPD | Qian W, et al. (2012) PMID:23103169 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
Addgene Plasmids | DNASU Plasmids | PlasmID | Thermo Scientific | YGRC
dHITS | FitDB | HIPHOP Chemogenomics | HIP HOP Profiles | MetaboGeneCard | PROPHECY | SCMD | ScreenTroll | TheCellVision | Yeast Phenome