Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
45 entries for 15 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| apoptosis: decreased | classical genetics | null Allele: sip3-Δ | W303 | 60 μM amiodarone | Details: decreased sensitivity to amiodarone-induced regulated cell death; survival increased from 5% in wt cells to 18% in the null mutant | Sokolov SS, et al. (2020) PMID:32564734 |
| chemical compound accumulation: increased | classical genetics | null Allele: sip3-Δ | S288C | ethanol | Treatment: vanillin, 7 mM Details: increased production of ethanol by the null mutant (8.6 g/l) at 24 hours relative to wt (3.6 g/l) in vanillin treated cells | Zhao F, et al. (2023) PMID:36528179 |
| chromosome/plasmid maintenance: abnormal | large-scale survey assay for maintenance of 5ORIdelta-deltaR fragment (derivative of Chromosome III lacking all efficient origins) | null Allele: sip3-Δ | S288C | Details: originless fragment maintenance (Ofm) phenotype | Theis JF, et al. (2010) PMID:21151954 | |
| competitive fitness: decreased | systematic mutation set fitness profiling after 15 generations | null Allele: sip3-Δ | S288C | 10 uM nystatin | Giaever G, et al. (2002) PMID:12140549 | |
| competitive fitness: decreased | systematic mutation set fitness profiling after 5 generations | null Allele: sip3-Δ | S288C | 10 uM nystatin | Giaever G, et al. (2002) PMID:12140549 | |
| competitive fitness: increased | competitive growth fitness profiling using complete deletion alleles | null Allele: sip3-Δ | S288C | Media: minimal medium Details: Relative fitness score: 1.004 | Breslow DK, et al. (2008) PMID:18622397 | |
| competitive fitness: increased | systematic mutation set | null Allele: sip3-Δ | S288C | Media: synthetic complete medium, SC | Qian W, et al. (2012) PMID:23103169 | |
| desiccation resistance: decreased | homozygous diploid, systematic mutation set | null Allele: sip3-Δ | S288C | Treatment: pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth Details: 2-fold or greater decreased survival after the treatment | Ratnakumar S, et al. (2011) PMID:20963216 | |
| growth in exponential phase: increased rate | classical genetics | null Allele: sip3-Δ | S288C | 7 mM vanillin | Details: shorter lag phase and better growth on vanillin-containing media with a fermentable carbon source relative to wt | Zhao F, et al. (2023) PMID:36528179 |
| heat sensitivity: increased | systematic mutation set | null Allele: sip3-Δ | S288C | Temperature: elevated temperature, 39 °C Details: medium heat-sensitivity | Ruiz-Roig C, et al. (2010) PMID:20398213 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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