CSL4 / YNL232W Homology
- Standard Name
- CSL4 1
- Systematic Name
- YNL232W
- SGD ID
- SGD:S000005176
- Aliases
- SKI4 15 16
- Feature Type
- ORF , Verified
- Description
- Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; human homolog EXOSC1 partially complements yeast csl4 null mutant, and can complement inviability of strain in which expression of CSL4 is repressed 1 2 3 4 5 6
- Name Description
- Cep1 Synthetic Lethal 1
- Comparative Info
-
Homologs
Homology calls are sourced from the Alliance of Genome Resources. Many aspects of data integration presented at the Alliance require a common set of orthology relationships among genes for the organisms represented, including human. The Alliance provides the results of all methods that have been benchmarked by the Quest for Orthologs Consortium (QfO). The homolog inferences from the different methods have been integrated using the DRSC Integrative Ortholog Prediction Tool (DIOPT), which integrates a number of existing methods including those used by the Alliance: Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, and ZFIN.
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| HOMOLOG ID | Species | Gene ID | Gene name | Source |
|---|
Functional Complementation
Information about cross-species functional complementation between yeast and other species, curated by SGD and the Princeton Protein Orthology Database (P-POD).
4 entries for 4 complementsIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
| Species | Gene ID | Strain background | Direction | Details | Source | Reference |
|---|---|---|---|---|---|---|
| Homo sapiens | HGNC:17286 | Other | other complements yeast | csl4-Δ is lethal but can be rescued by wild-type human EXOSC1; disease-related EXOSC1 variant Arg183Trp shows slow-growth phenotype, EXOSC1 variant Ser35Leu cannot rescue csl4-Δ yeast | SGD | Damseh NS, et al. (2023) PMID:37024942 |
| Homo sapiens | HGNC:17286 | S288C | other complements yeast | Human EXOSCI/CSL4 complements the inviability of a yeast strain in which expression of CSL4 is repressed. | SGD | Zhang N, et al. (2003) PMID:12559573 |
| Homo sapiens | HGNC:17286 | S288C | other complements yeast | According to this paper, human CSL4 (ENSP00000306711) partially complements a yeast csl4 null mutant. | P-POD | Baker RE, et al. (1998) PMID:9584087 |
| Homo sapiens | HGNC:17286 | S288C | other complements yeast | Codon optimized human and mouse EXOSC1 complement the S. cerevisiae csl4 null mutant, supporting growth similar to wt. | SGD | Ahammed KS, et al. (2025) PMID:39982806 |
Fungal Homologs
Fungal Homology calls are sourced from AllianceMine, which compiles fungal homology calls from FungiDB, CGD, Panther, PomBase, TreeFam, HomoloGene, and SGD.
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| HOMOLOG ID | Species | Gene ID | Gene name | Description | Source |
|---|
External Identifiers
List of external identifiers for the protein from various database sources.
28 entries for 11 sourcesIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
| External ID | Source |
|---|---|
| AN11250 | AspGD |
| orf19.1026 | CGD |
| 6785 | DIP |
| Z69381 | GenBank/EMBL/DDBJ |
| CAA93366.1 | GenBank/EMBL/DDBJ |
| CAA96137.1 | GenBank/EMBL/DDBJ |
| 448262641 | GenBank/EMBL/DDBJ |
| 6324097 | GenBank/EMBL/DDBJ |
| 1730832 | GenBank/EMBL/DDBJ |
| 1302259 | GenBank/EMBL/DDBJ |
Resources
Homologs
AGD | AnalogYeast | AspGD | BLASTP at NCBI | CGD | FungiDB | PhylomeDB | PomBase | YGOB | YOGY
Protein Databases
AlphaFold Protein Structure | GPMDB | ModelArchive | Pfam domains | SUPERFAMILY | TopologYeast | UniProtKB
Localization
CYCLoPs | dHITS | LoQAtE | YeastGFP | YeastRC Public Images | YeastRGB | YPL+
Post-translational Modifications
CoSMoS.c. | PhosphoGRID | PhosphoPep
S288C only
BLASTN | BLASTP | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species
BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi