Phenotype Help

PBR1 / YNL181W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.


Summary
PBR1/YNL181W is an essential gene, null mutant is inviable; heterozygous diploid null is haploinsufficient, sensitive to flucytosine and to isoniazide; repressible allele leads to accumulation of cells with 1C DNA content indicative of G1 arrest or delay; conditional allele leads to no growth at 37 °C; overexpression slows vegetative growth in S288C, increases filamentous growth in Sigma1278b

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

15 entries for 11 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
cell cycle progression in G1 phase: abnormal
large-scale surveyrepressibleS288CDetails: accumulation of cells with a 1C DNA content indicative of a G1 arrest or delay
Yu L, et al. (2006) PMID:16943325
competitive fitness: decreased
competitive growth

fitness profiling of essential genes using hypomorphic DAmP alleles

reduction of functionS288CMedia: minimal medium
Details: Relative fitness score: 0.948
Breslow DK, et al. (2008) PMID:18622397
filamentous growth: increased
systematic mutation setoverexpressionSigma1278bJin R, et al. (2008) PMID:17989363
haploinsufficient
heterozygous diploid, competitive growthnull
Allele: pbr1-Δ
S288CTreatment: conditions that mimic Phase II of a batch fermentation, equivalent to ~22 hours after inoculation of a batch fermentation
Novo M, et al. (2013) PMID:24040173
haploinsufficient
heterozygous diploid, systematic mutation set null
Allele: pbr1-Δ
S288COhnuki S and Ohya Y (2018) PMID:29768403
heat sensitivity: increased
large-scale surveyconditional
Allele: ynl181w-ts
S288CTemperature: elevated temperature, 37 °C
Details: no growth; slow growth at other temperatures
Ben-Aroya S, et al. (2008) PMID:18439903
inviable
systematic mutation setnull
Allele: pbr1-Δ
S288CGiaever G, et al. (2002) PMID:12140549
resistance to chemicals: decreased
heterozygous diploid, systematic mutation set null
Allele: pbr1-Δ
S288C200 ng/mL flucytosineLum PY, et al. (2004) PMID:14718172
resistance to chemicals: decreased
heterozygous diploid, systematic mutation set null
Allele: pbr1-Δ
S288C275 μg/mL isoniazideLum PY, et al. (2004) PMID:14718172
resistance to chemicals: decreased
systematic mutation setconditional
Allele: ynl181w-5014
S288C10 ug/mL micafunginForster DT, et al. (2022) PMID:36192463
Showing 1 to 10 of 15 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


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Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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