Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
13 entries for 7 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| haploproficient | heterozygous diploid, competitive growth genome-wide fitness profiling | null Allele: mfa2-Δ | S288C | Media: turbidostat growth in FPM medium Details: Relative growth score: 0.0022 | Pir P, et al. (2012) PMID:22244311 | |
| resistance to chemicals: decreased | systematic mutation set | null Allele: mfa2-Δ | S288C | spermine | Barreto L, et al. (2011) PMID:21724935 | |
| resistance to chemicals: decreased | systematic mutation set | null Allele: mfa2-Δ | S288C | hygromycin B | Barreto L, et al. (2011) PMID:21724935 | |
| resistance to chemicals: decreased | homozygous diploid, systematic mutation set | null Allele: mfa2-Δ | S288C | benzo[a]pyrene | O'Connor ST, et al. (2012) PMID:23403841 | |
| resistance to chemicals: decreased | systematic mutation set | null Allele: mfa2-Δ | S288C | CG-1521 | Gaupel AC, et al. (2014) PMID:24968945 | |
| resistance to chemicals: increased | systematic mutation set | null Allele: mfa2-Δ | S288C | 60 uM edelfosine | Cuesta-Marbán Á, et al. (2013) PMID:23335509 | |
| resistance to chemicals: increased | systematic mutation set | null Allele: mfa2-Δ | S288C | 1 uM myriocin | Fröhlich F, et al. (2015) PMID:26357016 | |
| reticulophagy: decreased | systematic mutation set | null Allele: mfa2-Δ | S288C | 200 ng/ml sirolimus | Details: specific defect in ER-phagy after rapamycin-induced starvation based on vacuolar transport and degradation of Sec61-mCherry and Rtn1-GFP; subset is not defective in bulk autophagy as assayed by vacuolar delivery of GFP-Atg8 | Chen S, et al. (2020) PMID:32690699 |
| toxin resistance: increased | systematic mutation set | null Allele: mfa2-Δ | S288C | Treatment: Aβ42 Details: increased resistance to the toxicity of Aβ42, a 42 AA aggregate prone proteolytic product of the human amyloid precursor protein (APP) | Chen X, et al. (2020) PMID:32054832 | |
| vegetative growth: decreased | systematic mutation set | null Allele: mfa2-Δ | S288C | 0.67 mM 5-hydroxymethylfurfural, 30 mM acetic acid, 4.5 mM furfural | Treatment: inhibitor-supplemented synthetic hydrolysate | Pereira FB, et al. (2014) PMID:25287021 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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