Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
19 entries for 10 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| chemical compound accumulation: increased | homozygous diploid | null Allele: nrk1-Δ | S288C | cobalt(2+) | Treatment: cobalt dichloride, 1 mM Details: cobalt sensitive null mutant accumulates cobalt after treatment with CoCl2 for 12 hrs | Zhao YY, et al. (2020) PMID:31904504 |
| chemical compound accumulation: increased | homozygous diploid | null Allele: nrk1-Δ | S288C | reactive oxygen species | Treatment: cobalt dichloride, 1 mM Details: increased intracellular accumulation of ROS in cells treated with CoCl2 for 12 hrs; possible defect in scavenging oxidative stress | Zhao YY, et al. (2020) PMID:31904504 |
| chemical compound accumulation: increased | homozygous diploid | null Allele: nrk1-Δ | S288C | zinc(2+) | Treatment: zinc dichloride, 3 mM Details: zinc sensitive null mutant accumulates Zn2+ after treatment with ZnCl2 for 2 hrs | Zhao YY, et al. (2020) PMID:31836620 |
| chemical compound accumulation: increased | homozygous diploid | null Allele: nrk1-Δ | S288C | reactive oxygen species | Treatment: zinc dichloride, 3 mM Details: increased intracellular accumulation of ROS in cells treated with 3 mM ZnCl2 for 2 hrs | Zhao YY, et al. (2020) PMID:31836620 |
| chemical compound accumulation: increased | homozygous diploid | null Allele: nrk1-Δ | S288C | reactive oxygen species | Treatment: zinc dichloride, 8 mM Details: increased intracellular accumulation of ROS in cells treated with 8 mM ZnCl2 for 5 hrs | Zhao YY, et al. (2020) PMID:31836620 |
| chemical compound accumulation: increased | homozygous diploid | null Allele: nrk1-Δ | S288C | reactive oxygen species | Treatment: sodium dodecyl sulfate, 0.015 % Details: increased accumulation of ROS relative to wt after treatment for 2hr with SDS | Cao C, et al. (2020) PMID:32066383 |
| chemical compound excretion: increased | classical genetics | null Allele: nrk1-Δ | S288C | N-ribosylnicotinamide | Lu SP and Lin SJ (2011) PMID:21349851 | |
| competitive fitness: decreased | competitive growth fitness profiling using complete deletion alleles | null Allele: nrk1-Δ | S288C | Media: minimal medium Details: Relative fitness score: 0.955 | Breslow DK, et al. (2008) PMID:18622397 | |
| haploinsufficient | heterozygous diploid, competitive growth genome-wide fitness profiling | null Allele: nrk1-Δ | S288C | Media: turbidostat growth in FPM medium Details: Relative growth score: -0.0038 | Pir P, et al. (2012) PMID:22244311 | |
| prion formation: decreased Reporter: [GAR+] prion | systematic mutation set | null Allele: nrk1-Δ | S288C | Details: reduced [GAR+] induction upon exposure to Staphylococcus hominis | Jarosz DF, et al. (2014) PMID:25171409 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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