Phenotype Help

MIC27 / YNL100W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.



Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

20 entries for 15 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
competitive fitness: decreased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: mic27-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 0.978
Breslow DK, et al. (2008) PMID:18622397
competitive fitness: increased
systematic mutation setnull
Allele: mic27-Δ
S288CMedia: rich medium (YPD) w/6% ethanol, ETH
Qian W, et al. (2012) PMID:23103169
endocytosis: decreased
Reporter: Mup1-pHluorin
systematic mutation set null
Allele: mic27-Δ
S288CMedia: nitrogen starvation
Details: class 1 mutant specifically defective in starvation-induced internalization of Mup1p with fluorescence remaining at the plasma membrane; not required for methionine-induced endocytosis
Ivashov V, et al. (2020) PMID:32744498
mitochondrial genome maintenance: abnormal
large-scale surveynull
Allele: mic27-Δ
S288CDetails: decreased frequency of spontaneous mitochondrial genome loss
Hess DC, et al. (2009) PMID:19300474
mitochondrial morphology: abnormal
classical geneticsnull
Allele: mic27-Δ
S288CDetails: reduced number of crista junctions and accumulation of internal cristae stacks
Harner M, et al. (2011) PMID:22009199
mitochondrial morphology: abnormal
classical geneticsnull
Allele: mic27-Δ
S288CDetails: many cells exhibit lamellar stacks of cristae not connected to the inner boundary membrane, and the number of cristae junctions is reduced
von der Malsburg K, et al. (2011) PMID:21944719
mitochondrial morphology: abnormal
classical geneticsnull
Allele: mic27-Δ
W303Details: at least 70% of cells accumulate aberrant lamellar membrane sheets within mitochondria; cristae are also abnormally long and misshapen
Hoppins S, et al. (2011) PMID:21987634
oxidative stress resistance: decreased
systematic mutation setnull
Allele: mic27-Δ
S288C0.125 mM cumene hydroperoxideHiggins VJ, et al. (2002) PMID:11816028
oxidative stress resistance: decreased
competitive growth null
Allele: mic27-Δ
S288C1 mM paraquatHelsen J, et al. (2020) PMID:32658971
resistance to chemicals: decreased
systematic mutation setnull
Allele: mic27-Δ
S288C40 mg/ml streptomycinAlamgir M, et al. (2010) PMID:20691087
Showing 1 to 10 of 20 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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