Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
68 entries for 18 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| cell cycle progression in G1 phase: abnormal | classical genetics | null Allele: oca1-Δ | S288C | 0.04 mM linoleic acid hydroperoxide | Details: defective in the linoleic acid hydroperoxide (LoaOOH)-induced G1 delay observed in wt cells; budding and replication delays are much shorter than in the wt strain and the timing of Start is not delayed | Alic N, et al. (2001) PMID:11408586 |
| cell cycle progression in G1 phase: abnormal | classical genetics | null Allele: oca1-Δ | S288C | 40 μM linoleic acid hydroperoxide | Details: reduction in the linoleic acid hydroperoxide (LoaOOH)-induced G1 delay that is observed in wt cells | Alic N, et al. (2003) PMID:12912987 |
| cell death: decreased | classical genetics | null Allele: oca1-Δ | Other | 4 mM hydrogen peroxide | Details: viability increased relative to wt after treatment with H2O2 | Singh K, et al. (2019) PMID:30670610 |
| chemical compound accumulation: abnormal | systematic mutation set | null Allele: oca1-Δ | S288C | alpha-amino acid | Details: Significantly altered free amino acid profile (X^2- test adjusted p < 0.01), showing 11 simultaneous amino acid changes (Z-test, adjusted p < 0.01) | Mülleder M, et al. (2016) PMID:27693354 |
| chemical compound accumulation: decreased | homozygous diploid, systematic mutation set glycogen accumulation in diploid mutant strains grown in microtiter plates | null Allele: oca1-Δ | S288C | glycogen | Wilson WA, et al. (2002) PMID:12096123 | |
| chemical compound accumulation: decreased | systematic mutation set | null Allele: oca1-Δ | S288C | serine | Mülleder M, et al. (2016) PMID:27693354 | |
| chemical compound accumulation: decreased | systematic mutation set | null Allele: oca1-Δ | S288C | proline | Mülleder M, et al. (2016) PMID:27693354 | |
| chemical compound accumulation: decreased | systematic mutation set | null Allele: oca1-Δ | S288C | glutamine | Mülleder M, et al. (2016) PMID:27693354 | |
| chemical compound accumulation: decreased | systematic mutation set | null Allele: oca1-Δ | S288C | glutamate(1-) | Mülleder M, et al. (2016) PMID:27693354 | |
| chemical compound accumulation: decreased | systematic mutation set | null Allele: oca1-Δ | S288C | aspartate(1-) | Mülleder M, et al. (2016) PMID:27693354 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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