Gene Ontology Help

PHO23 / YNL097C Gene Ontology

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations.


Summary
Histone-binding component of the Rpd3L histone deacetylase complex involved in chromatin organization, modification, and silencing at telomeres, the rDNA, and the mating-type cassette; regulates transcription in response to stressors such as heat and glucose limitation
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

ion binding, protein-macromolecule adaptor activity, chromatin organization, response to heat, response to stress, nucleus, organelle, Rpd3L complex, Rpd3L-Expanded complex, Sin3-type complex, histone deacetylase complex

Manually Curated

Manually curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually curated annotations are assigned by SGD curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.


Biological Process 10 entries for 7 Gene Ontology terms

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

QualifierGene Ontology TermAnnotation ExtensionEvidenceSourceAssigned OnReference
involved inchromatin organizationIMPSGD2016-09-04Loewith R, et al. (2000) PMID:10805724
involved innegative regulation of transcription by RNA polymerase IIMPSGD2013-08-07Hontz RD, et al. (2009) PMID:19270272
involved incellular response to heatIMPSGD2024-03-20Ruiz-Roig C, et al. (2010) PMID:20398213
involved inpositive regulation of transcription by RNA polymerase IIIMPSGD2013-08-07Sertil O, et al. (2007) PMID:17210643
involved inpositive regulation of transcription by RNA polymerase IIpart of cellular response to heat, has input ALD3IMPSGD2022-06-03Ruiz-Roig C, et al. (2010) PMID:20398213
involved inpositive regulation of transcription by RNA polymerase IIpart of cellular response to heatIMPSGD2022-06-03Ruiz-Roig C, et al. (2010) PMID:20398213
involved inpositive regulation of transcription by RNA polymerase IIpart of cellular response to heat, has input CTT1IMPSGD2022-06-03Ruiz-Roig C, et al. (2010) PMID:20398213
involved innegative regulation of silent mating-type cassette heterochromatin formationIMPSGD2013-08-07Keogh MC, et al. (2005) PMID:16286008
involved innegative regulation of rDNA heterochromatin formationIMPSGD2013-08-07Keogh MC, et al. (2005) PMID:16286008
involved inpositive regulation of invasive growth in response to glucose limitationIMPSGD2014-09-26Barrales RR, et al. (2008) PMID:18202364
Showing 1 to 10 of 10 entries

Molecular Function

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Gene/Complex Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference

Cellular Component

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Gene/Complex Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference

High-throughput

GO annotations from high-throughput experiments are based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than SGD curators. While SGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation may not necessarily be reviewed by a curator. GO annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned to terms from all three controlled vocabularies of the Gene Ontology.


Biological Process

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Gene/Complex Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference

Molecular Function

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Gene/Complex Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference

Cellular Component

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Gene/Complex Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference

Computational

Computational GO Annotations are predictions. These annotations are NOT reviewed by a curator. Currently, all computational GO annotations for S. cerevisiae are assigned by an external source (for example, the Gene Ontology Annotation (GOA) project of the European Bioinformatics Institute (EBI)).


Biological Process

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Gene/Complex Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference

Molecular Function

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Gene/Complex Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference

Cellular Component

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Gene/Complex Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference

Shared Annotations

This diagram displays manually curated and high-throughput GO terms (green squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of GO terms shared (adjustable using the slider at the bottom).


Reset

Click on a gene or Biological Process GO term name to go to its specific page within SGD; drag any of the gene or GO term name objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share GO Biological Process terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.

9101112