Sequence Help

TOP2 / YNL088W Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

TOR3 , TRF3 16
Protein Product
DNA topoisomerase 2
Feature Type
ORF , Verified
Topoisomerase II; relieves torsional strain in DNA by cleaving and re-sealing phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation; human homolog TOP2A implicated in cancers, and can complement yeast null mutant 2 3 4 5 7 8 9
EC Number