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NOP2 / YNL061W Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

YNA1 8
Protein Product
rRNA (cytosine-C5-)-methyltransferase NOP2
Feature Type
ORF , Verified
rRNA m5C methyltransferase; methylates cytosine at position 2870 of 25S rRNA; has an essential function independent of rRNA methylation; contains seven beta-strand methyltransferase motif; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles; rRNA methylation defect and lethality are functionally complemented by human NOP2, a gene upregulated in cancer 1 2 3 4 5 6 7
EC Number