IDH1 / YNL037C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Non-essential gene; the null mutant exhibits a wide range of phenotypes includubg abnormal actin cytoskeleton morphology and decreased biofilm formation, indicating alterations in cell structure and adhesion properties. Mutants demonstrate poor chromosome and plasmid maintenance, as evidenced by large-scale survey assays. Chronological lifespan is diminished, and mutant strains show reduced competitive fitness during growth. The heterozygous diploid null is haploinsufficient. Mitochondrial genome maintenance is compromised in idh1 mutants, especially with specific mutations like A119R affecting isocitrate binding. The replicative lifespan is prolonged in these mutants, indicating a relationship between IDH1 function and cellular aging. While resistance to various chemicals is primarily decreased, there are instances of increased resistance to specific compounds. Mutant strains exhibit decreased respiratory growth rates and lower resistance to starvation. Moreover, they show absent or significantly reduced utilization of carbon sources, hampering metabolic flexibility. Nitrogen source utilization is also impaired, alongside overall decreased vegetative growth rates.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources