Literature Help
RRN9 / YMR270C Literature
All manually curated literature for the specified gene, organized by relevance to the gene and by
association with specific annotations to the gene in SGD. SGD gathers references via a PubMed search for
papers whose titles or abstracts contain “yeast” or “cerevisiae;” these papers are reviewed manually and
linked to relevant genes and literature topics by SGD curators.
Primary Literature
Literature that either focuses on the gene or contains information about function, biological role,
cellular location, phenotype, regulation, structure, or disease homologs in other species for the gene
or gene product.
No primary literature curated.
Download References (.nbib)
- Zhou C, et al. (2024) The de novo design and synthesis of yeast chromosome XIII facilitates investigations on aging. Nat Commun 15(1):10139 PMID:39578428
- Baudin F, et al. (2022) Mechanism of RNA polymerase I selection by transcription factor UAF. Sci Adv 8(16):eabn5725 PMID:35442737
- Knutson BA, et al. (2020) Molecular Topology of RNA Polymerase I Upstream Activation Factor. Mol Cell Biol 40(13) PMID:32253346
- Iida T and Kobayashi T (2019) RNA Polymerase I Activators Count and Adjust Ribosomal RNA Gene Copy Number. Mol Cell 73(4):645-654.e13 PMID:30612878
- Smith ML, et al. (2018) Reconstitution of RNA Polymerase I Upstream Activating Factor and the Roles of Histones H3 and H4 in Complex Assembly. J Mol Biol 430(5):641-654 PMID:29357286
- Ha CW, et al. (2012) Nsi1 plays a significant role in the silencing of ribosomal DNA in Saccharomyces cerevisiae. Nucleic Acids Res 40(11):4892-903 PMID:22362748
- Goetze H, et al. (2010) Alternative chromatin structures of the 35S rRNA genes in Saccharomyces cerevisiae provide a molecular basis for the selective recruitment of RNA polymerases I and II. Mol Cell Biol 30(8):2028-45 PMID:20154141
- Oakes ML, et al. (2006) Role of histone deacetylase Rpd3 in regulating rRNA gene transcription and nucleolar structure in yeast. Mol Cell Biol 26(10):3889-901 PMID:16648483
- Bier M, et al. (2004) The composition of the RNA polymerase I transcription machinery switches from initiation to elongation mode. FEBS Lett 564(1-2):41-6 PMID:15094040
- Bordi L, et al. (2001) In vivo binding and hierarchy of assembly of the yeast RNA polymerase I transcription factors. Mol Biol Cell 12(3):753-60 PMID:11251085
- Siddiqi I, et al. (2001) Role of TATA binding protein (TBP) in yeast ribosomal dna transcription by RNA polymerase I: defects in the dual functions of transcription factor UAF cannot be suppressed by TBP. Mol Cell Biol 21(7):2292-7 PMID:11259579
- Siddiqi IN, et al. (2001) Transcription of chromosomal rRNA genes by both RNA polymerase I and II in yeast uaf30 mutants lacking the 30 kDa subunit of transcription factor UAF. EMBO J 20(16):4512-21 PMID:11500378
- Aprikian P, et al. (2000) TATA binding protein can stimulate core-directed transcription by yeast RNA polymerase I. Mol Cell Biol 20(14):5269-75 PMID:10866683
- Oakes M, et al. (1999) Transcription factor UAF, expansion and contraction of ribosomal DNA (rDNA) repeats, and RNA polymerase switch in transcription of yeast rDNA. Mol Cell Biol 19(12):8559-69 PMID:10567580
- Vu L, et al. (1999) RNA polymerase switch in transcription of yeast rDNA: role of transcription factor UAF (upstream activation factor) in silencing rDNA transcription by RNA polymerase II. Proc Natl Acad Sci U S A 96(8):4390-5 PMID:10200272
- Steffan JS, et al. (1998) Interaction of TATA-binding protein with upstream activation factor is required for activated transcription of ribosomal DNA by RNA polymerase I in Saccharomyces cerevisiae in vivo. Mol Cell Biol 18(7):3752-61 PMID:9632758
- Keys DA, et al. (1996) Multiprotein transcription factor UAF interacts with the upstream element of the yeast RNA polymerase I promoter and forms a stable preinitiation complex. Genes Dev 10(7):887-903 PMID:8846924
- Steffan JS, et al. (1996) The role of TBP in rDNA transcription by RNA polymerase I in Saccharomyces cerevisiae: TBP is required for upstream activation factor-dependent recruitment of core factor. Genes Dev 10(20):2551-63 PMID:8895657
- Nogi Y, et al. (1991) An approach for isolation of mutants defective in 35S ribosomal RNA synthesis in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 88(16):7026-30 PMID:1871118
Related Literature
Genes that share literature (indicated by the purple circles) with the specified gene (indicated by yellow circle).
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Additional Literature
Papers that show experimental evidence for the gene or describe homologs in other species, but
for which the gene is not the paper’s principal focus.
No additional literature curated.
Download References (.nbib)
- Lanz MC, et al. (2021) In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Rep 22(2):e51121 PMID:33491328
- Pilsl M, et al. (2016) Analysis of S. cerevisiae RNA Polymerase I Transcription In Vitro. Methods Mol Biol 1455:99-108 PMID:27576713
- Tremblay M, et al. (2014) UV light-induced DNA lesions cause dissociation of yeast RNA polymerases-I and establishment of a specialized chromatin structure at rRNA genes. Nucleic Acids Res 42(1):380-95 PMID:24097442
- Neumüller RA, et al. (2013) Conserved regulators of nucleolar size revealed by global phenotypic analyses. Sci Signal 6(289):ra70 PMID:23962978
- Tang X, et al. (2013) Clustering based on multiple biological information: approach for predicting protein complexes. IET Syst Biol 7(5):223-30 PMID:24067423
- Carter R and Drouin G (2009) The evolutionary rates of eukaryotic RNA polymerases and of their transcription factors are affected by the level of concerted evolution of the genes they transcribe. Mol Biol Evol 26(11):2515-20 PMID:19633229
- Beckouet F, et al. (2008) Two RNA polymerase I subunits control the binding and release of Rrn3 during transcription. Mol Cell Biol 28(5):1596-605 PMID:18086878
- Breslow DK, et al. (2008) A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods 5(8):711-8 PMID:18622397
- Meier A and Thoma F (2005) RNA polymerase I transcription factors in active yeast rRNA gene promoters enhance UV damage formation and inhibit repair. Mol Cell Biol 25(5):1586-95 PMID:15713619
- Cioci F, et al. (2003) Silencing in yeast rDNA chromatin: reciprocal relationship in gene expression between RNA polymerase I and II. Mol Cell 12(1):135-45 PMID:12887899
- Liu M, et al. (2002) Characterization of the fission yeast ribosomal DNA binding factor: components share homology with Upstream Activating Factor and with SWI/SNF subunits. Nucleic Acids Res 30(24):5347-59 PMID:12490702
- Keener J, et al. (1998) Reconstitution of yeast RNA polymerase I transcription in vitro from purified components. TATA-binding protein is not required for basal transcription. J Biol Chem 273(50):33795-802 PMID:9837969
- Vogelauer M, et al. (1998) DNA protein-interactions at the Saccharomyces cerevisiae 35 S rRNA promoter and in its surrounding region. J Mol Biol 275(2):197-209 PMID:9466903
- Keener J, et al. (1997) Histones H3 and H4 are components of upstream activation factor required for the high-level transcription of yeast rDNA by RNA polymerase I. Proc Natl Acad Sci U S A 94(25):13458-62 PMID:9391047
- Lalo D, et al. (1996) RRN11 encodes the third subunit of the complex containing Rrn6p and Rrn7p that is essential for the initiation of rDNA transcription by yeast RNA polymerase I. J Biol Chem 271(35):21062-7 PMID:8702872
- Nogi Y, et al. (1993) Gene RRN4 in Saccharomyces cerevisiae encodes the A12.2 subunit of RNA polymerase I and is essential only at high temperatures. Mol Cell Biol 13(1):114-22 PMID:8417319
Reviews
No reviews curated.
Download References (.nbib)
- Daiß JL, et al. (2023) Synthesis of the ribosomal RNA precursor in human cells: mechanisms, factors and regulation. Biol Chem 404(11-12):1003-1023 PMID:37454246
- Dörner K, et al. (2023) Ribosome biogenesis factors-from names to functions. EMBO J 42(7):e112699 PMID:36762427
- Schwank K, et al. (2023) Features of yeast RNA polymerase I with special consideration of the lobe binding subunits. Biol Chem 404(11-12):979-1002 PMID:37823775
- Knutson BA and Hahn S (2013) TFIIB-related factors in RNA polymerase I transcription. Biochim Biophys Acta 1829(3-4):265-73 PMID:22960599
- Woolford JL and Baserga SJ (2013) Ribosome biogenesis in the yeast Saccharomyces cerevisiae. Genetics 195(3):643-81 PMID:24190922
- Schneider DA (2012) RNA polymerase I activity is regulated at multiple steps in the transcription cycle: recent insights into factors that influence transcription elongation. Gene 493(2):176-84 PMID:21893173
- Nomura M (2011) Journey of a molecular biologist. Annu Rev Biochem 80:16-40 PMID:21456966
- Cioci F, et al. (2007) DNA protein interactions at the rRNA of Saccharomyces cerevisiae. Ital J Biochem 56(2):81-90 PMID:17722648
- Conconi A (2005) The yeast rDNA locus: a model system to study DNA repair in chromatin. DNA Repair (Amst) 4(8):897-908 PMID:15996904
- Grummt I (2003) Life on a planet of its own: regulation of RNA polymerase I transcription in the nucleolus. Genes Dev 17(14):1691-702 PMID:12865296
- Moss T and Stefanovsky VY (2002) At the center of eukaryotic life. Cell 109(5):545-8 PMID:12062097
- Reeder RH (1999) Regulation of RNA polymerase I transcription in yeast and vertebrates. Prog Nucleic Acid Res Mol Biol 62:293-327 PMID:9932458
- Warner JR (1999) The economics of ribosome biosynthesis in yeast. Trends Biochem Sci 24(11):437-40 PMID:10542411
Gene Ontology Literature
Paper(s) associated with one or more GO (Gene Ontology) terms in SGD for the specified gene.
No gene ontology literature curated.
Download References (.nbib)
- Ha CW, et al. (2012) Nsi1 plays a significant role in the silencing of ribosomal DNA in Saccharomyces cerevisiae. Nucleic Acids Res 40(11):4892-903 PMID:22362748
- Steffan JS, et al. (1998) Interaction of TATA-binding protein with upstream activation factor is required for activated transcription of ribosomal DNA by RNA polymerase I in Saccharomyces cerevisiae in vivo. Mol Cell Biol 18(7):3752-61 PMID:9632758
- Keys DA, et al. (1996) Multiprotein transcription factor UAF interacts with the upstream element of the yeast RNA polymerase I promoter and forms a stable preinitiation complex. Genes Dev 10(7):887-903 PMID:8846924
Phenotype Literature
Paper(s) associated with one or more pieces of classical phenotype evidence in SGD for the specified gene.
No phenotype literature curated.
Download References (.nbib)
- Zhou C, et al. (2024) The de novo design and synthesis of yeast chromosome XIII facilitates investigations on aging. Nat Commun 15(1):10139 PMID:39578428
- Nogi Y, et al. (1991) An approach for isolation of mutants defective in 35S ribosomal RNA synthesis in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 88(16):7026-30 PMID:1871118
Interaction Literature
Paper(s) associated with evidence supporting a physical or genetic interaction between the
specified gene and another gene in SGD. Currently, all interaction evidence is obtained from
BioGRID.
No interaction literature curated.
Download References (.nbib)
- Andrade Latino A and Biggins S (2025) Analysis of a cancer-associated mutation in the budding yeast Nuf2 kinetochore protein. MicroPubl Biol 2025 PMID:40161439
- Michaelis AC, et al. (2023) The social and structural architecture of the yeast protein interactome. Nature 624(7990):192-200 PMID:37968396
- Mattingly M, et al. (2022) Mediator recruits the cohesin loader Scc2 to RNA Pol II-transcribed genes and promotes sister chromatid cohesion. Curr Biol 32(13):2884-2896.e6 PMID:35654035
- den Brave F, et al. (2020) Chaperone-Mediated Protein Disaggregation Triggers Proteolytic Clearance of Intra-nuclear Protein Inclusions. Cell Rep 31(9):107680 PMID:32492414
- Knutson BA, et al. (2020) Molecular Topology of RNA Polymerase I Upstream Activation Factor. Mol Cell Biol 40(13) PMID:32253346
- Miller JE, et al. (2018) Genome-Wide Mapping of Decay Factor-mRNA Interactions in Yeast Identifies Nutrient-Responsive Transcripts as Targets of the Deadenylase Ccr4. G3 (Bethesda) 8(1):315-330 PMID:29158339
- Smith ML, et al. (2018) Reconstitution of RNA Polymerase I Upstream Activating Factor and the Roles of Histones H3 and H4 in Complex Assembly. J Mol Biol 430(5):641-654 PMID:29357286
- Lapointe CP, et al. (2017) Architecture and dynamics of overlapped RNA regulatory networks. RNA 23(11):1636-1647 PMID:28768715
- Costanzo M, et al. (2016) A global genetic interaction network maps a wiring diagram of cellular function. Science 353(6306) PMID:27708008
- Dubarry M, et al. (2015) Genetic Networks Required to Coordinate Chromosome Replication by DNA Polymerases α, δ, and ε in Saccharomyces cerevisiae. G3 (Bethesda) 5(10):2187-97 PMID:26297725
- van Pel DM, et al. (2013) Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork. G3 (Bethesda) 3(2):273-82 PMID:23390603
- Gilmore JM, et al. (2012) Characterization of a highly conserved histone related protein, Ydl156w, and its functional associations using quantitative proteomic analyses. Mol Cell Proteomics 11(4):M111.011544 PMID:22199229
- Sharifpoor S, et al. (2012) Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs. Genome Res 22(4):791-801 PMID:22282571
- García-Gómez JJ, et al. (2011) Dynamics of the putative RNA helicase Spb4 during ribosome assembly in Saccharomyces cerevisiae. Mol Cell Biol 31(20):4156-64 PMID:21825077
- Breitkreutz A, et al. (2010) A global protein kinase and phosphatase interaction network in yeast. Science 328(5981):1043-6 PMID:20489023
- Batisse J, et al. (2009) Purification of nuclear poly(A)-binding protein Nab2 reveals association with the yeast transcriptome and a messenger ribonucleoprotein core structure. J Biol Chem 284(50):34911-7 PMID:19840948
- Yu H, et al. (2008) High-quality binary protein interaction map of the yeast interactome network. Science 322(5898):104-10 PMID:18719252
- Wong J, et al. (2007) A protein interaction map of the mitotic spindle. Mol Biol Cell 18(10):3800-9 PMID:17634282
- Oakes ML, et al. (2006) Role of histone deacetylase Rpd3 in regulating rRNA gene transcription and nucleolar structure in yeast. Mol Cell Biol 26(10):3889-901 PMID:16648483
- Ito T, et al. (2001) A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc Natl Acad Sci U S A 98(8):4569-74 PMID:11283351
- Siddiqi IN, et al. (2001) Transcription of chromosomal rRNA genes by both RNA polymerase I and II in yeast uaf30 mutants lacking the 30 kDa subunit of transcription factor UAF. EMBO J 20(16):4512-21 PMID:11500378
- Aprikian P, et al. (2000) TATA binding protein can stimulate core-directed transcription by yeast RNA polymerase I. Mol Cell Biol 20(14):5269-75 PMID:10866683
- Uetz P, et al. (2000) A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature 403(6770):623-7 PMID:10688190
- Oakes M, et al. (1999) Transcription factor UAF, expansion and contraction of ribosomal DNA (rDNA) repeats, and RNA polymerase switch in transcription of yeast rDNA. Mol Cell Biol 19(12):8559-69 PMID:10567580
- Keener J, et al. (1998) Reconstitution of yeast RNA polymerase I transcription in vitro from purified components. TATA-binding protein is not required for basal transcription. J Biol Chem 273(50):33795-802 PMID:9837969
- Steffan JS, et al. (1998) Interaction of TATA-binding protein with upstream activation factor is required for activated transcription of ribosomal DNA by RNA polymerase I in Saccharomyces cerevisiae in vivo. Mol Cell Biol 18(7):3752-61 PMID:9632758
- Keener J, et al. (1997) Histones H3 and H4 are components of upstream activation factor required for the high-level transcription of yeast rDNA by RNA polymerase I. Proc Natl Acad Sci U S A 94(25):13458-62 PMID:9391047
- Steffan JS, et al. (1996) The role of TBP in rDNA transcription by RNA polymerase I in Saccharomyces cerevisiae: TBP is required for upstream activation factor-dependent recruitment of core factor. Genes Dev 10(20):2551-63 PMID:8895657
Regulation Literature
Paper(s) associated with one or more pieces of regulation evidence in SGD, as found on the
Regulation page.
No regulation literature curated.
Post-translational Modifications Literature
Paper(s) associated with one or more pieces of post-translational modifications evidence in SGD.
No post-translational modifications literature curated.
High-Throughput Literature
Paper(s) associated with one or more pieces of high-throughput evidence in SGD.
No high-throughput literature curated.
Download References (.nbib)
- Ohnuki S and Ohya Y (2018) High-dimensional single-cell phenotyping reveals extensive haploinsufficiency. PLoS Biol 16(5):e2005130 PMID:29768403
- Pir P, et al. (2012) The genetic control of growth rate: a systems biology study in yeast. BMC Syst Biol 6:4 PMID:22244311
- Yoshikawa K, et al. (2011) Comprehensive phenotypic analysis of single-gene deletion and overexpression strains of Saccharomyces cerevisiae. Yeast 28(5):349-61 PMID:21341307
- Breslow DK, et al. (2008) A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods 5(8):711-8 PMID:18622397
- Hu Z, et al. (2007) Genetic reconstruction of a functional transcriptional regulatory network. Nat Genet 39(5):683-7 PMID:17417638
- Sopko R, et al. (2006) Mapping pathways and phenotypes by systematic gene overexpression. Mol Cell 21(3):319-30 PMID:16455487
- Lum PY, et al. (2004) Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes. Cell 116(1):121-37 PMID:14718172
- Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91 PMID:12140549