Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
14 entries for 7 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| chromosome/plasmid maintenance: decreased | heterozygous diploid, systematic mutation set | null Allele: prp24-Δ | S288C | Assay: diploid bimater (BiM) assay Details: haploinsufficiency results in chromosome instability (CIN); scored >= 2 standard deviations above the mean | Choy JS, et al. (2013) PMID:23825022 | |
| competitive fitness: decreased | competitive growth fitness profiling of essential genes using hypomorphic DAmP alleles | reduction of function | S288C | Media: minimal medium Details: Relative fitness score: 0.993 | Breslow DK, et al. (2008) PMID:18622397 | |
| heat sensitivity: increased | classical genetics | conditional | Other | Temperature: elevated temperature, 37 °C | Vijayraghavan U, et al. (1989) PMID:2676722 | |
| heat sensitivity: increased | heterozygous diploid, systematic mutation set pooled screening for fitness defects at 37 deg C relative to 30 deg C | null Allele: prp24-Δ | S288C | Temperature: elevated temperature, 37 °C | Sinha H, et al. (2008) PMID:18780730 | |
| inviable | systematic mutation set | null Allele: prp24-Δ | S288C | Giaever G, et al. (2002) PMID:12140549 | ||
| resistance to chemicals: decreased | systematic mutation set Decreased Abundance by mRNA Perturbation (DAmP) library of haploid strains | reduction of function | S288C | methyl methanesulfonate | Svensson JP, et al. (2011) PMID:21978764 | |
| resistance to chemicals: decreased | heterozygous diploid, systematic mutation set | null Allele: prp24-Δ | S288C | 20 μg/mL actinomycin D | Lum PY, et al. (2004) PMID:14718172 | |
| resistance to chemicals: decreased | heterozygous diploid, systematic mutation set | null Allele: prp24-Δ | S288C | 3 μg/mL doxorubicin | Lum PY, et al. (2004) PMID:14718172 | |
| resistance to chemicals: decreased | systematic mutation set | reduction of function Allele: prp24-DAmP hypomorphic allele in which a 3' UTR insertion reduces mRNA stability | S288C | 1 ng/ml sirolimus | Details: sirolimus is rapamycin | van Pel DM, et al. (2013) PMID:23390603 |
| resistance to chemicals: increased | systematic mutation set | repressible | S288C | 1 uM myriocin | Fröhlich F, et al. (2015) PMID:26357016 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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