Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
24 entries for 17 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| cell fusion: decreased | classical genetics | null Allele: fus2-Δ | Other | Treatment: mated to wild type cells Details: defective in cell fusion with increased prezygote formation, in which cell walls fuse but membranes do not | Dorer R, et al. (1997) PMID:9135999 | |
| cell fusion: decreased | classical genetics | null Allele: fus2-Δ | Other | Details: bilateral defect; most arrest as prezygotes with a complete septum, unfused nuclei (90%) and some cytoplasmic mixing; defective in the removal of the cell wall at an extended zone of cell fusion and adjacent to the fusion pore; membrane abnormalities at the fusion zone | Gammie AE, et al. (1998) PMID:9614182 | |
| cell fusion: decreased | classical genetics | null Allele: fus2-Δ | Other | Details: defective nuclear migration, vesicle accumulation, cell wall degradation and membrane fusion during cellular fusion | Elia L and Marsh L (1998) PMID:9744878 | |
| cell fusion: decreased | classical genetics | null Allele: fus2-1 | Other | Details: leaky bilateral defect; prezygotes display an aberrant junction or plate which fails to degrade; some nuclear fusion occurs; some instance of cytoplasmic mixing | Trueheart J, et al. (1987) PMID:3302672 | |
| cell fusion: decreased | classical genetics | reduction of function Allele: fus2-ΔDbl deletion of Dbl-homology domain | Other | Details: large number of unfused and partially unfused zygotes; phenotype not as strong as null strain | Ydenberg CA, et al. (2012) PMID:22323294 | |
| chemical compound accumulation: abnormal | classical genetics | null Allele: fus2-Δ | S288C | (1->3)-beta-D-glucan | Treatment: alpha-factor Details: increased staining along the entire surface of the shmoo projection, contrasting with wt cells which stain along the sides and base but not the tip of the projection | Fitch PG, et al. (2004) PMID:15514049 |
| chemical compound accumulation: decreased | classical genetics | null Allele: fus2-Δ | S288C | calcium(2+) | Treatment: alpha-factor Details: decreased low-affinity Ca2+ influx | Muller EM, et al. (2003) PMID:12878605 |
| chromosome/plasmid maintenance: decreased | heterozygous diploid, systematic mutation set | null Allele: fus2-Δ | S288C | Assay: diploid bimater (BiM) assay Details: haploinsufficiency results in chromosome instability (CIN); scored >= 2 standard deviations above the mean | Choy JS, et al. (2013) PMID:23825022 | |
| haploinsufficient | heterozygous diploid, competitive growth genome-wide fitness profiling | null Allele: fus2-Δ | S288C | Media: turbidostat growth in FPM medium Details: Relative growth score: -0.0054 | Pir P, et al. (2012) PMID:22244311 | |
| mating efficiency: decreased | classical genetics | null Allele: fus2-Δ | Other | Treatment: mated with pheromoneless partner in presence high concentrations of alpha-factor Details: defective in default mating pathway, which operates in the absence of a pheromone gradient | Dorer R, et al. (1997) PMID:9135999 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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