Phenotype Help

HFD1 / YMR110C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.


Summary
Non-essential gene; null mutant is sensitive to extracellular sphingosine and dihydrosphingosine

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

10 entries for 9 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
chemical compound accumulation: decreased
systematic mutation setnull
Allele: hfd1-Δ
S288C ubiquinonesPayet LA, et al. (2016) PMID:27693056
chemical compound accumulation: decreased
classical genetics null
Allele: hfd1-Δ
W303 ubiquinonesDetails: loss of coenzyme Q (ubiquinone) and its early mitochondrial precursor, polyprenyl-4-hydroxybenzoate
Kemmerer ZA, et al. (2021) PMID:34362905
competitive fitness: decreased
systematic mutation setnull
Allele: hfd1-Δ
S288CMedia: glycerol medium, YPG
Qian W, et al. (2012) PMID:23103169
competitive fitness: normal
competitive growth

fitness profiling using complete deletion alleles

null
Allele: hfd1-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 1
Breslow DK, et al. (2008) PMID:18622397
haploproficient
heterozygous diploid, competitive growth

genome-wide fitness profiling

null
Allele: hfd1-Δ
S288CMedia: turbidostat growth in FPM medium
Details: Relative growth score: 0.0033
Pir P, et al. (2012) PMID:22244311
resistance to chemicals: decreased
classical geneticsnull
Allele: hfd1-Δ
S288C1 uM sphingosine(1+)Details: Similar results seen with dihydrosphingosine
Nakahara K, et al. (2012) PMID:22633490
respiratory growth: decreased
systematic mutation setnull
Allele: hfd1-Δ
S288CPayet LA, et al. (2016) PMID:27693056
transposable element transposition: increased
Reporter: his3-A1
systematic mutation setnull
Allele: hfd1-Δ
S288CNyswaner KM, et al. (2008) PMID:18202368
vacuolar morphology: abnormal
systematic mutation set

screen all non-essential genes for inability to fragment vacuoles in response to salt addition

null
Allele: hfd1-Δ
S288C0.4 M sodium chlorideDetails: small defect in vacuolar fragmentation
Michaillat L and Mayer A (2013) PMID:23383298
viable
systematic mutation setnull
Allele: hfd1-Δ
S288CGiaever G, et al. (2002) PMID:12140549
Showing 1 to 10 of 10 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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