Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
41 entries for 14 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| bipolar budding pattern: decreased | homozygous diploid | null Allele: myo5-Δ | Other | Details: small increase in random and unipolar-distal budding patterns of older cells (>= 5 bud scars) | Tuo S, et al. (2013) PMID:24039741 | |
| budding: abnormal | classical genetics | reduction of function Allele: myo5-S357A myosin I TEDS site, phosphorylation required for polarization of actin cytoskeleton | Other | Details: myo3Δ background; almost 80% of small budded cells exhibited clearly depolarized actin cytoskeleton with >2 actin patches present at mother cells | Grosshans BL, et al. (2006) PMID:16478726 | |
| budding: abnormal | classical genetics | reduction of function Allele: myo5-S357E myosin I TEDS site, phosphorylation required for polarization of actin cytoskeleton | Other | Details: myo3Δ background; nearly 30% of small budded cells exhibited depolarized cytoskeleton | Grosshans BL, et al. (2006) PMID:16478726 | |
| cold sensitivity: increased | classical genetics | reduction of function Allele: myo5-S357A myosin I TEDS site, phosphorylation required for polarization of actin cytoskeleton | Other | Temperature: permissive temperature, 23 °C Details: myo3Δ background | Grosshans BL, et al. (2006) PMID:16478726 | |
| competitive fitness: decreased | systematic mutation set fitness profiling after 15 generations | null Allele: myo5-Δ | S288C | 10 uM nystatin | Giaever G, et al. (2002) PMID:12140549 | |
| competitive fitness: decreased | systematic mutation set fitness profiling after 5 generations | null Allele: myo5-Δ | S288C | 10 uM nystatin | Giaever G, et al. (2002) PMID:12140549 | |
| competitive fitness: decreased | competitive growth fitness profiling using complete deletion alleles | null Allele: myo5-Δ | S288C | Media: minimal medium Details: Relative fitness score: 0.987 | Breslow DK, et al. (2008) PMID:18622397 | |
| endocytosis: decreased | classical genetics | null Allele: myo5-Δ | S288C | Details: defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2 reporter | Burston HE, et al. (2009) PMID:19506040 | |
| endocytosis: decreased | systematic mutation set | null Allele: myo5-Δ | S288C | Details: defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2 | Burston HE, et al. (2009) PMID:19506040 | |
| endocytosis: decreased | classical genetics | null Allele: myo5-Δ | Other | Details: decrease in clathrin-mediated endocytosis, assayed by pulse-label with the membrane dye FM4-64; ~35% internalized compared to ~80% in wt cells | Hill JM, et al. (2024) PMID:38899037 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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