Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
23 entries for 14 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| auxotrophy | classical genetics | null Allele: arg7-Δ | Sigma1278b | arginine | Details: leaky phenotype, with some poor growth in the absence of arginine | Crabeel M, et al. (1997) PMID:9428669 |
| auxotrophy | classical genetics | null Allele: arg7-T215A T215A; catalytic pentad residue mutated; catalytically inactive; defective in autocatalytic activation | S288C | Details: poor growth on media lacking arginine; similar results with other catalytic pentad residue mutants (D179A, K204A, S253A and D256A) | Fung D, et al. (2025) PMID:40140419 | |
| chemical compound accumulation: abnormal | systematic mutation set | null Allele: arg7-Δ | S288C | alpha-amino acid | Details: Significantly altered free amino acid profile (X^2- test adjusted p < 0.01), showing 4 simultaneous amino acid changes (Z-test, adjusted p < 0.01) | Mülleder M, et al. (2016) PMID:27693354 |
| chemical compound accumulation: decreased | systematic mutation set | null Allele: arg7-Δ | S288C | methionine | Mülleder M, et al. (2016) PMID:27693354 | |
| chemical compound accumulation: decreased | systematic mutation set | null Allele: arg7-Δ | S288C | proline | Mülleder M, et al. (2016) PMID:27693354 | |
| chemical compound accumulation: increased | systematic mutation set | null Allele: arg7-Δ | S288C | tyrosine | Mülleder M, et al. (2016) PMID:27693354 | |
| chemical compound accumulation: increased | systematic mutation set | null Allele: arg7-Δ | S288C | asparagine | Mülleder M, et al. (2016) PMID:27693354 | |
| competitive fitness: decreased | systematic mutation set fitness profiling after 15 generations | null Allele: arg7-Δ | S288C | Media: synthetic medium, minimal +his/leu/ura medium | Giaever G, et al. (2002) PMID:12140549 | |
| mitotic recombination: decreased | systematic mutation set | null Allele: arg7-Δ | S288C | Details: spontaneous direct-repeat hypo-recombination identified using a high-throughput replica-pinning technique; recombination frequency of less than 33% compared to 56% for wt | Novarina D, et al. (2020) PMID:32265288 | |
| oxidative stress resistance: decreased | classical genetics | null Allele: arg7-Δ | S288C | 5 mM hydrogen peroxide | Martínez-Pastor M, et al. (2010) PMID:20955007 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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