AIM33 / YML087C Overview

Standard Name
AIM33 1
Systematic Name
Feature Type
ORF , Verified
Protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication 1 2 3
Name Description
Altered Inheritance rate of Mitochondria 1
PGA3 3
Comparative Info
Sequence Details


The S. cerevisiae Reference Genome sequence is derived from laboratory strain S288C. Download DNA or protein sequence, view genomic context and coordinates. Click "Sequence Details" to view all sequence information for this locus, including that for other strains.

AIM33 is located on the left arm of chromosome XIII between ARS1305 origin of replication and ALO1 D-arabinono-1,4-lactone oxidase; coding sequence is 939 nucleotides long with 13 SNPs, 3 of which cause amino acid polymorphisms; AIM33 has paralog PGA3 from the whole genome duplication
Protein Details


Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein.

Aim33p is 312 amino acids long, low in abundance; contains 6 cytochrome B5 reductase signatures
Length (a.a.)
Mol. Weight (Da)
Isoelectric Point


Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results.

View all AIM33 alleles in SGD search

Gene Ontology Details

Gene Ontology

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations. Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes.

Protein whose biological role and cellular location are unknown

View computational annotations

Molecular Function

Manually Curated

Biological Process

Manually Curated

Cellular Component

Manually Curated
Phenotype Details


Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided. Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes.

Non-essential gene; null mutant displays increased competitive fitness in synthetic complete medium, but an inability to grow on medium containing a non-fermentable carbon source; null mutant has a reduced frequency of spontaneous mitochondrial genome loss; null mutant displays decreased accumulation of calcium and sodium ions; null mutant has decreased resistance to both ethanol, and starvation stress
Interaction Details


Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference, as well as other experimental details. Click "Interaction Details" to view all interaction annotations and evidence for this locus, including an interaction visualization.

Aim33p interacts physically with proteins involved in translation regulation and RNA catabolism; AIM33 interacts genetically with genes involved in transcription and DNA repair; the aim33 null mutant is viable, the null mutant of paralog pga3 is viable, the aim33 pga3 double mutant has not been annotated for phenotype

127 total interactions for 109 unique genes

Physical Interactions

  • Affinity Capture-RNA: 4
  • PCA: 1
  • Reconstituted Complex: 1

Genetic Interactions

  • Negative Genetic: 66
  • Positive Genetic: 53
  • Synthetic Rescue: 2
Regulation Details


The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. This evidence includes data generated through high-throughput techniques. Click "Regulation Details" to view all regulation annotations, shared GO enrichment among regulation Targets, and a regulator/target diagram for the locus.

AIM33 promoter is bound by Tfc7p in response to heat; AIM33 RNA is stabilized by Pbp1p
Expression Details


Expression data are derived from records contained in the Gene Expression Omnibus (GEO), and are first log2 transformed and normalized. Referenced datasets may contain one or more condition(s), and as a result there may be a greater number of conditions than datasets represented in a single clickable histogram bar. The histogram division at 0.0 separates the down-regulated (green) conditions and datasets from those that are up-regulated (red). Click "Expression Details" to view all expression annotations and details for this locus, including a visualization of genes that share a similar expression pattern.

Summary Paragraph

A summary of the locus, written by SGD Biocurators following a thorough review of the literature. Links to gene names and curated GO terms are included within the Summary Paragraphs.

Last Updated: 2024-07-01

Literature Details


All manually curated literature for the specified gene, organized into topics according to their relevance to the gene (Primary Literature, Additional Literature, or Review). Click "Literature Details" to view all literature information for this locus, including shared literature between genes.