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HMG1 / YML075C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.


Protein Product
hydroxymethylglutaryl-CoA reductase (NADPH) HMG1
Feature Type
ORF , Verified
Description
HMG-CoA reductase; catalyzes conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to nuclear envelope; overproduction induces formation of karmellae; forms foci at nuclear periphery upon DNA replication stress; HMG1 has a paralog, HMG2, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg1 mutant 1 2 3 4 5 6 7 8 9
Paralog
HMG2 7
EC Number
1.1.1.34

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