Literature Help
NSE5 / YML023C Literature
All manually curated literature for the specified gene, organized by relevance to the gene and by
association with specific annotations to the gene in SGD. SGD gathers references via a PubMed search for
papers whose titles or abstracts contain “yeast” or “cerevisiae;” these papers are reviewed manually and
linked to relevant genes and literature topics by SGD curators.
Primary Literature
Literature that either focuses on the gene or contains information about function, biological role,
cellular location, phenotype, regulation, structure, or disease homologs in other species for the gene
or gene product.
No primary literature curated.
Download References (.nbib)
- Phipps J, et al. (2025) Cohesin complex oligomerization maintains end-tethering at DNA double-strand breaks. Nat Cell Biol 27(1):118-129 PMID:39482358
- Li Q, et al. (2024) Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms. Nat Struct Mol Biol 31(10):1532-1542 PMID:38890552
- Berg MD, et al. (2022) Genetic background and mistranslation frequency determine the impact of mistranslating tRNASerUGG. G3 (Bethesda) 12(7) PMID:35587152
- Hallett ST, et al. (2021) Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex. Nucleic Acids Res 49(8):4534-4549 PMID:33849072
- Taschner M, et al. (2021) Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding. EMBO J 40(15):e107807 PMID:34191293
- Yu Y, et al. (2021) Integrative analysis reveals unique structural and functional features of the Smc5/6 complex. Proc Natl Acad Sci U S A 118(19) PMID:33941673
- Gutierrez-Escribano P, et al. (2020) Purified Smc5/6 Complex Exhibits DNA Substrate Recognition and Compaction. Mol Cell 80(6):1039-1054.e6 PMID:33301732
- Peng XP, et al. (2018) Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites. PLoS Genet 14(1):e1007129 PMID:29360860
- Rai R and Laloraya S (2017) Genetic evidence for functional interaction of Smc5/6 complex and Top1 with spatial frequency of replication origins required for maintenance of chromosome stability. Curr Genet 63(4):765-776 PMID:28204881
- Bonner JN, et al. (2016) Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates. Cell Rep 16(2):368-378 PMID:27373152
- Bustard DE, et al. (2016) Non-Smc element 5 (Nse5) of the Smc5/6 complex interacts with SUMO pathway components. Biol Open 5(6):777-85 PMID:27215325
- Peng J and Feng W (2016) Incision of damaged DNA in the presence of an impaired Smc5/6 complex imperils genome stability. Nucleic Acids Res 44(21):10216-10229 PMID:27536003
- Bermúdez-López M, et al. (2015) ATPase-dependent control of the Mms21 SUMO ligase during DNA repair. PLoS Biol 13(3):e1002089 PMID:25764370
- Menolfi D, et al. (2015) Essential Roles of the Smc5/6 Complex in Replication through Natural Pausing Sites and Endogenous DNA Damage Tolerance. Mol Cell 60(6):835-46 PMID:26698660
- Novo M, et al. (2013) Genome-wide study of the adaptation of Saccharomyces cerevisiae to the early stages of wine fermentation. PLoS One 8(9):e74086 PMID:24040173
- Bustard DE, et al. (2012) During replication stress, non-SMC element 5 (NSE5) is required for Smc5/6 protein complex functionality at stalled forks. J Biol Chem 287(14):11374-83 PMID:22303010
- Leung GP, et al. (2011) Rtt107 is required for recruitment of the SMC5/6 complex to DNA double strand breaks. J Biol Chem 286(29):26250-7 PMID:21642432
- Bermúdez-López M, et al. (2010) The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages. Nucleic Acids Res 38(19):6502-12 PMID:20571088
- Ben-Aroya S, et al. (2008) Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Mol Cell 30(2):248-58 PMID:18439903
- Torres-Rosell J, et al. (2007) Anaphase onset before complete DNA replication with intact checkpoint responses. Science 315(5817):1411-5 PMID:17347440
- Betts Lindroos H, et al. (2006) Chromosomal association of the Smc5/6 complex reveals that it functions in differently regulated pathways. Mol Cell 22(6):755-767 PMID:16793545
- Zhao X and Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82 PMID:15738391
Related Literature
Genes that share literature (indicated by the purple circles) with the specified gene (indicated by yellow circle).
Reset
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Additional Literature
Papers that show experimental evidence for the gene or describe homologs in other species, but
for which the gene is not the paper’s principal focus.
No additional literature curated.
Download References (.nbib)
- Oravcová M, et al. (2022) The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers. Elife 11 PMID:36373674
- Lanz MC, et al. (2021) In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Rep 22(2):e51121 PMID:33491328
- Parts L, et al. (2021) Natural variants suppress mutations in hundreds of essential genes. Mol Syst Biol 17(5):e10138 PMID:34042294
- Varejão N, et al. (2021) Structural basis for the E3 ligase activity enhancement of yeast Nse2 by SUMO-interacting motifs. Nat Commun 12(1):7013 PMID:34853311
- Kuzmin E, et al. (2018) Systematic analysis of complex genetic interactions. Science 360(6386) PMID:29674565
- Horigome C, et al. (2016) PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL. Genes Dev 30(8):931-45 PMID:27056668
- Carlborg KK, et al. (2015) Mec1-dependent phosphorylation of Mms21 modulates its SUMO ligase activity. DNA Repair (Amst) 28:83-92 PMID:25659338
- Ben-Shitrit T, et al. (2012) Systematic identification of gene annotation errors in the widely used yeast mutation collections. Nat Methods 9(4):373-8 PMID:22306811
- Jung PP, et al. (2011) Ploidy influences cellular responses to gross chromosomal rearrangements in Saccharomyces cerevisiae. BMC Genomics 12:331 PMID:21711526
- Kegel A, et al. (2011) Chromosome length influences replication-induced topological stress. Nature 471(7338):392-6 PMID:21368764
- Ohouo PY, et al. (2010) DNA damage signaling recruits the Rtt107-Slx4 scaffolds via Dpb11 to mediate replication stress response. Mol Cell 39(2):300-6 PMID:20670896
- Duan X, et al. (2009) Architecture of the Smc5/6 Complex of Saccharomyces cerevisiae Reveals a Unique Interaction between the Nse5-6 Subcomplex and the Hinge Regions of Smc5 and Smc6. J Biol Chem 284(13):8507-15 PMID:19141609
- Breslow DK, et al. (2008) A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods 5(8):711-8 PMID:18622397
- De Piccoli G, et al. (2006) Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination. Nat Cell Biol 8(9):1032-4 PMID:16892052
- Snoek IS and Steensma HY (2006) Why does Kluyveromyces lactis not grow under anaerobic conditions? Comparison of essential anaerobic genes of Saccharomyces cerevisiae with the Kluyveromyces lactis genome. FEMS Yeast Res 6(3):393-403 PMID:16630279
- Hazbun TR, et al. (2003) Assigning function to yeast proteins by integration of technologies. Mol Cell 12(6):1353-65 PMID:14690591
Reviews
No reviews curated.
Gene Ontology Literature
Paper(s) associated with one or more GO (Gene Ontology) terms in SGD for the specified gene.
No gene ontology literature curated.
Phenotype Literature
Paper(s) associated with one or more pieces of classical phenotype evidence in SGD for the specified gene.
No phenotype literature curated.
Download References (.nbib)
- Ben-Aroya S, et al. (2008) Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Mol Cell 30(2):248-58 PMID:18439903
- Torres-Rosell J, et al. (2007) Anaphase onset before complete DNA replication with intact checkpoint responses. Science 315(5817):1411-5 PMID:17347440
- Zhao X and Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82 PMID:15738391
Interaction Literature
Paper(s) associated with evidence supporting a physical or genetic interaction between the
specified gene and another gene in SGD. Currently, all interaction evidence is obtained from
BioGRID.
No interaction literature curated.
Download References (.nbib)
- Li S, et al. (2023) Molecular basis for Nse5-6 mediated regulation of Smc5/6 functions. Proc Natl Acad Sci U S A 120(45):e2310924120 PMID:37903273
- Michaelis AC, et al. (2023) The social and structural architecture of the yeast protein interactome. Nature 624(7990):192-200 PMID:37968396
- Pradhan B, et al. (2023) The Smc5/6 complex is a DNA loop-extruding motor. Nature 616(7958):843-848 PMID:37076626
- Yu Y, et al. (2022) Cryo-EM structure of DNA-bound Smc5/6 reveals DNA clamping enabled by multi-subunit conformational changes. Proc Natl Acad Sci U S A 119(23):e2202799119 PMID:35648833
- Taschner M, et al. (2021) Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding. EMBO J 40(15):e107807 PMID:34191293
- Varejão N, et al. (2021) Structural basis for the E3 ligase activity enhancement of yeast Nse2 by SUMO-interacting motifs. Nat Commun 12(1):7013 PMID:34853311
- Yu Y, et al. (2021) Integrative analysis reveals unique structural and functional features of the Smc5/6 complex. Proc Natl Acad Sci U S A 118(19) PMID:33941673
- Gutierrez-Escribano P, et al. (2020) Purified Smc5/6 Complex Exhibits DNA Substrate Recognition and Compaction. Mol Cell 80(6):1039-1054.e6 PMID:33301732
- Sanders E, et al. (2020) Comprehensive Synthetic Genetic Array Analysis of Alleles That Interact with Mutation of the Saccharomyces cerevisiae RecQ Helicases Hrq1 and Sgs1. G3 (Bethesda) 10(12):4359-4368 PMID:33115720
- Kuzmin E, et al. (2018) Systematic analysis of complex genetic interactions. Science 360(6386) PMID:29674565
- Peng XP, et al. (2018) Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites. PLoS Genet 14(1):e1007129 PMID:29360860
- Babour A, et al. (2016) The Chromatin Remodeler ISW1 Is a Quality Control Factor that Surveys Nuclear mRNP Biogenesis. Cell 167(5):1201-1214.e15 PMID:27863241
- Bustard DE, et al. (2016) Non-Smc element 5 (Nse5) of the Smc5/6 complex interacts with SUMO pathway components. Biol Open 5(6):777-85 PMID:27215325
- Costanzo M, et al. (2016) A global genetic interaction network maps a wiring diagram of cellular function. Science 353(6306) PMID:27708008
- Horigome C, et al. (2016) PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL. Genes Dev 30(8):931-45 PMID:27056668
- Bermúdez-López M, et al. (2015) ATPase-dependent control of the Mms21 SUMO ligase during DNA repair. PLoS Biol 13(3):e1002089 PMID:25764370
- Hang LE, et al. (2015) Rtt107 Is a Multi-functional Scaffold Supporting Replication Progression with Partner SUMO and Ubiquitin Ligases. Mol Cell 60(2):268-79 PMID:26439300
- Kanno T, et al. (2015) The Smc5/6 Complex Is an ATP-Dependent Intermolecular DNA Linker. Cell Rep 12(9):1471-82 PMID:26299966
- Bustard DE, et al. (2012) During replication stress, non-SMC element 5 (NSE5) is required for Smc5/6 protein complex functionality at stalled forks. J Biol Chem 287(14):11374-83 PMID:22303010
- del Alamo M, et al. (2011) Defining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes. PLoS Biol 9(7):e1001100 PMID:21765803
- Leung GP, et al. (2011) Rtt107 is required for recruitment of the SMC5/6 complex to DNA double strand breaks. J Biol Chem 286(29):26250-7 PMID:21642432
- Michelot A, et al. (2010) Reconstitution and protein composition analysis of endocytic actin patches. Curr Biol 20(21):1890-9 PMID:21035341
- Ohouo PY, et al. (2010) DNA damage signaling recruits the Rtt107-Slx4 scaffolds via Dpb11 to mediate replication stress response. Mol Cell 39(2):300-6 PMID:20670896
- Batisse J, et al. (2009) Purification of nuclear poly(A)-binding protein Nab2 reveals association with the yeast transcriptome and a messenger ribonucleoprotein core structure. J Biol Chem 284(50):34911-7 PMID:19840948
- Duan X, et al. (2009) Architecture of the Smc5/6 Complex of Saccharomyces cerevisiae Reveals a Unique Interaction between the Nse5-6 Subcomplex and the Hinge Regions of Smc5 and Smc6. J Biol Chem 284(13):8507-15 PMID:19141609
- Yu H, et al. (2008) High-quality binary protein interaction map of the yeast interactome network. Science 322(5898):104-10 PMID:18719252
- Zhao X and Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82 PMID:15738391
- Hazbun TR, et al. (2003) Assigning function to yeast proteins by integration of technologies. Mol Cell 12(6):1353-65 PMID:14690591
- Ito T, et al. (2001) A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc Natl Acad Sci U S A 98(8):4569-74 PMID:11283351
Regulation Literature
Paper(s) associated with one or more pieces of regulation evidence in SGD, as found on the
Regulation page.
No regulation literature curated.
Post-translational Modifications Literature
Paper(s) associated with one or more pieces of post-translational modifications evidence in SGD.
No post-translational modifications literature curated.
High-Throughput Literature
Paper(s) associated with one or more pieces of high-throughput evidence in SGD.
No high-throughput literature curated.
Download References (.nbib)
- Forster DT, et al. (2022) BIONIC: biological network integration using convolutions. Nat Methods 19(10):1250-1261 PMID:36192463
- Chen X, et al. (2020) FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism. Nat Commun 11(1):867 PMID:32054832
- Ohnuki S and Ohya Y (2018) High-dimensional single-cell phenotyping reveals extensive haploinsufficiency. PLoS Biol 16(5):e2005130 PMID:29768403
- Fröhlich F, et al. (2015) The GARP complex is required for cellular sphingolipid homeostasis. Elife 4 PMID:26357016
- Neumüller RA, et al. (2013) Conserved regulators of nucleolar size revealed by global phenotypic analyses. Sci Signal 6(289):ra70 PMID:23962978
- Novo M, et al. (2013) Genome-wide study of the adaptation of Saccharomyces cerevisiae to the early stages of wine fermentation. PLoS One 8(9):e74086 PMID:24040173
- van Pel DM, et al. (2013) Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork. G3 (Bethesda) 3(2):273-82 PMID:23390603
- Stirling PC, et al. (2011) The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components. PLoS Genet 7(4):e1002057 PMID:21552543
- Svensson JP, et al. (2011) Genomic phenotyping of the essential and non-essential yeast genome detects novel pathways for alkylation resistance. BMC Syst Biol 5:157 PMID:21978764
- Venters BJ, et al. (2011) A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces. Mol Cell 41(4):480-92 PMID:21329885
- Ben-Aroya S, et al. (2008) Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Mol Cell 30(2):248-58 PMID:18439903
- Breslow DK, et al. (2008) A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods 5(8):711-8 PMID:18622397
- Cipollina C, et al. (2008) Saccharomyces cerevisiae SFP1: at the crossroads of central metabolism and ribosome biogenesis. Microbiology (Reading) 154(Pt 6):1686-1699 PMID:18524923
- Snoek IS and Steensma HY (2006) Why does Kluyveromyces lactis not grow under anaerobic conditions? Comparison of essential anaerobic genes of Saccharomyces cerevisiae with the Kluyveromyces lactis genome. FEMS Yeast Res 6(3):393-403 PMID:16630279
- Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91 PMID:12140549