Phenotype Help

UNG1 / YML021C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.


Summary
Non-essential gene; null mutant is sensitive to gamma rays in the presence of aminopterin and sulfanilamide; point mutant displays elevated mutation frequency; null mutant is resistant to 5-fluorouracil; null and point mutants are sensitive to 4-aminofolic acid and sulfanilamide, sodium nitrite, and sodium hydrogensulfite; null mutant shows greater replicative lifespan extension in response to caloric restriction than does wild type; in large-scale studies, the null mutant shows increased competitive fitness in some media and decreased fitness in others; null mutant has elevated sensitivity to heat and osmotic stress

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

38 entries for 23 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
cell cycle progression through the G2/M phase transition: arrested
classical geneticsnull
Allele: ung1-Δ
Other100 ug/ml 4-aminofolic acid, 5 mg/ml sulfanilamideDetails: null mutant does not display an early S phase arrest due to checkpoint activation, like the control
Elateri I, et al. (2003) PMID:12547394
chemical compound accumulation: abnormal
systematic mutation setnull
Allele: ung1-Δ
S288C alpha-amino acidDetails: Significantly altered free amino acid profile (X^2- test p < 0.01), showing 1 simultaneous amino acid change (Z-test, adjusted p < 0.01)
Mülleder M, et al. (2016) PMID:27693354
chemical compound accumulation: decreased
systematic mutation setnull
Allele: ung1-Δ
S288C sodium(1+)Yu D, et al. (2012) PMID:23151179
chemical compound accumulation: increased
systematic mutation setnull
Allele: ung1-Δ
S288C cadmium cationYu D, et al. (2012) PMID:23151179
chemical compound accumulation: increased
systematic mutation setnull
Allele: ung1-Δ
S288C alanineMülleder M, et al. (2016) PMID:27693354
chronological lifespan: increased
competitive growth

competitive survival of stationary phase co-cultures

null
Allele: ung1-Δ
S288CGaray E, et al. (2014) PMID:24586198
competitive fitness: decreased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: ung1-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 0.998
Breslow DK, et al. (2008) PMID:18622397
competitive fitness: decreased
systematic mutation setnull
Allele: ung1-Δ
S288CMedia: synthetic oak exudate medium, OAK
Qian W, et al. (2012) PMID:23103169
competitive fitness: increased
competitive growthnull
Allele: ung1-Δ
S288CMedia: YPD
Qian W, et al. (2012) PMID:23103169
competitive fitness: increased
systematic mutation setnull
Allele: ung1-Δ
S288C ethanolQian W, et al. (2012) PMID:23103169
Showing 1 to 10 of 38 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


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