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HMG2 / YLR450W Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.


Protein Product
hydroxymethylglutaryl-CoA reductase (NADPH) HMG2
Feature Type
ORF , Verified
Description
HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at nuclear periphery upon DNA replication stress; HMG2 has a paralog, HMG1, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg2 mutant 1 2 3 4 5 6 7 8
Paralog
HMG1 6
EC Number
1.1.1.34

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