VMA6 / YLR447C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

VMA6/YLR447C is a non-essential gene in reference strain S288C. Null mutants are viable but display a range of defects, including decreased replicative and chronological lifespans, absent respiratory growth and sporulation, increased mutation frequency, abnormal vacuolar and lipid particle morphology, heightened sensitivity to UV radiation, heat, and hyperosmotic stress, decreased resistance to alkaline pH and oxidative stress, prolonged cell cycle progression in the G1 phase, reduced competitive fitness, and slower vegetative growth. Overexpression of VMA6 leads to a decreased rate of vegetative growth. These observations indicate that VMA6 is crucial for maintaining vacuolar function, stress resistance, proper lipid particle morphology, and overall cellular fitness, although it is not strictly required for survival under normal conditions.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources