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SIR3 / YLR442C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

CMT1 30 , MAR2 31 32 , STE8 33
Protein Product
chromatin-silencing protein SIR3
Feature Type
ORF , Verified
Silencing protein; interacts with Sir2p, Sir4p, and histone H3/H4 tails to establish transcriptionally silent chromatin; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p; C-terminus assumes variant winged helix-turn-helix (wH) fold that mediates homodimerization, which is critical for holo-SIR complex loading; required for telomere hypercluster formation in quiescent yeast cells; has paralog ORC1 from whole genome duplication 1 2 3 4 5 6 7
ORC1 5