Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
15 entries for 11 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| competitive fitness: increased | competitive growth fitness profiling using complete deletion alleles | null Allele: dif1-Δ | S288C | Media: minimal medium Details: Relative fitness score: 1.001 | Breslow DK, et al. (2008) PMID:18622397 | |
| desiccation resistance: decreased | systematic mutation set | null Allele: dif1-Δ | S288C | Details: less than 10% viability after dehydration stress | Rodríguez-Porrata B, et al. (2012) PMID:22181064 | |
| heat sensitivity: decreased | classical genetics | null Allele: dif1-Δ | S288C | Temperature: elevated temperature, 43 °C | Kim E and Siede W (2011) PMID:21369983 | |
| protein/peptide distribution: abnormal Reporter: ribonucleotide reductase subunit R2 Rnr2p and Rnr4p | classical genetics | null Allele: dif1-Δ | Other | Details: decreased percentage of cells with a predominantly nuclear localization pattern of Rnr2p and Rnr4p, relative to wild type cells | Wu X and Huang M (2008) PMID:18838542 | |
| protein/peptide distribution: abnormal Reporter: Rnr2p | classical genetics | overexpression | Other | Details: increased percentage of cells in which Rnr2p is predominantly nuclear localized, relative to wild type cells | Wu X and Huang M (2008) PMID:18838542 | |
| pseudohyphal growth: decreased | classical genetics | null Allele: dif1-Δ | S288C | Details: moderate carbon stress; 0.2% dextrose | Kim E and Siede W (2011) PMID:21369983 | |
| resistance to chemicals: decreased | classical genetics | null Allele: dif1-Δ | S288C | 100 mM hydroxyurea | Treatment: moderate carbon stress, 0.2% dextrose | Kim E and Siede W (2011) PMID:21369983 |
| resistance to chemicals: decreased | homozygous diploid, systematic mutation set | null Allele: dif1-Δ | S288C | benzo[a]pyrene | O'Connor ST, et al. (2012) PMID:23403841 | |
| resistance to chemicals: increased | homozygous diploid, systematic mutation set | null Allele: dif1-Δ | S288C | benzo[a]pyrene | O'Connor ST, et al. (2012) PMID:23403841 | |
| resistance to chemicals: increased | homozygous diploid, systematic mutation set | null Allele: dif1-Δ | S288C | 640 uM toxaphene | Gaytán BD, et al. (2013) PMID:24260565 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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