Phenotype Help

BLS1 / YLR408C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.


Summary
Non-essential gene in reference strain S288C; null mutant displays altered competitive fitness on various media; null mutant displays abnormal accumulation of polyphosphate and has an abnormal colony appearance on sucrose plates; null mutant has increased resistance to both canavanine and thialysine, indicative of an altered endocytic flux of amino acid permeases; heterozygous diploid null mutant has decreased starvation resistance and is haploinsufficient

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

21 entries for 10 phenotypes


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PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
chemical compound accumulation: abnormal
systematic mutation setnull
Allele: bls1-Δ
S288C polyphosphateFreimoser FM, et al. (2006) PMID:17107617
colony appearance: abnormal
systematic mutation setnull
Allele: bls1-Δ
Sigma1278bMedia: YP sucrose plates
Details: altered morphology compared to the wrinkled appearance of wt colonies
Voordeckers K, et al. (2012) PMID:22882838
competitive fitness: decreased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: bls1-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 0.976
Breslow DK, et al. (2008) PMID:18622397
competitive fitness: decreased
systematic mutation setnull
Allele: bls1-Δ
S288CMedia: synthetic oak exudate medium, OAK
Qian W, et al. (2012) PMID:23103169
competitive fitness: decreased
homozygous diploid, competitive growthnull
Allele: bls1-Δ
S288CTreatment: conditions that mimic Phase II of a batch fermentation, equivalent to ~22 hours after inoculation of a batch fermentation
Novo M, et al. (2013) PMID:24040173
competitive fitness: increased
systematic mutation setnull
Allele: bls1-Δ
S288CMedia: rich medium (YPD) w/6% ethanol, ETH
Qian W, et al. (2012) PMID:23103169
competitive fitness: increased
systematic mutation setnull
Allele: bls1-Δ
S288CMedia: synthetic complete medium, SC
Qian W, et al. (2012) PMID:23103169
haploinsufficient
heterozygous diploid, competitive growth

genome-wide fitness profiling

null
Allele: bls1-Δ
S288CMedia: turbidostat growth in FPM medium
Details: Relative growth score: -0.0058
Pir P, et al. (2012) PMID:22244311
resistance to chemicals: decreased
homozygous diploid, systematic mutation setnull
Allele: bls1-Δ
S288C benzo[a]pyreneO'Connor ST, et al. (2012) PMID:23403841
resistance to chemicals: decreased
homozygous diploid, systematic mutation setnull
Allele: bls1-Δ
S288C chondramide derivativeHoepfner D, et al. (2014) PMID:24360837
Showing 1 to 10 of 21 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


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