Phenotype Help

SPH1 / YLR313C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.



Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

20 entries for 12 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
bipolar budding pattern: abnormal
homozygous diploid null
Allele: sph1-Δ
W303Details: defective bud site selection resulting in decreased budding from the distal tip and increased proximal and random budding
Dittmar GA, et al. (2002) PMID:11923536
chemical compound accumulation: abnormal
systematic mutation setnull
Allele: sph1-Δ
S288C polyphosphateFreimoser FM, et al. (2006) PMID:17107617
chromosome/plasmid maintenance: decreased
heterozygous diploid, systematic mutation set overexpressionS288CDetails: mean frequency of loss of heterozygosity (LOH) at the CAN1 locus increased at least 2-fold; frequently accompanied by LOH at the MET6 locus indicating loss of the entire chr V
Tutaj H, et al. (2019) PMID:30244280
competitive fitness: decreased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: sph1-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 0.975
Breslow DK, et al. (2008) PMID:18622397
filamentous growth: decreased
systematic mutation setnull
Allele: sph1-Δ
Sigma1278bJin R, et al. (2008) PMID:17989363
haploproficient
heterozygous diploid, competitive growthnull
Allele: sph1-Δ
S288CTreatment: conditions that mimic Phase I of a batch fermentation, equivalent to ~14 hours after inoculation of a batch fermentation
Novo M, et al. (2013) PMID:24040173
mating projection morphology: abnormal
classical geneticsnull
Allele: sph1-Δ
S288CDetails: mating projections are more rounded than wild type
Roemer T, et al. (1998) PMID:9443897
mating projection morphology: abnormal
classical genetics null
Allele: sph1-Δ
W303Details: shmooing defects; form rounded or peanut-shaped morphology
Dittmar GA, et al. (2002) PMID:11923536
protein/peptide modification: decreased
Reporter: Slt2p
classical geneticsnull
Allele: sph1-Δ
OtherDetails: decreased levels of activated, phosphorylated Slt2p
Li X, et al. (2013) PMID:23924898
pseudohyphal growth: decreased
homozygous diploidnull
Allele: sph1-Δ
Sigma1278bMedia: nitrogen starvation
Roemer T, et al. (1998) PMID:9443897
Showing 1 to 10 of 20 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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