Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
20 entries for 12 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| bipolar budding pattern: abnormal | homozygous diploid | null Allele: sph1-Δ | W303 | Details: defective bud site selection resulting in decreased budding from the distal tip and increased proximal and random budding | Dittmar GA, et al. (2002) PMID:11923536 | |
| chemical compound accumulation: abnormal | systematic mutation set | null Allele: sph1-Δ | S288C | polyphosphate | Freimoser FM, et al. (2006) PMID:17107617 | |
| chromosome/plasmid maintenance: decreased | heterozygous diploid, systematic mutation set | overexpression | S288C | Details: mean frequency of loss of heterozygosity (LOH) at the CAN1 locus increased at least 2-fold; frequently accompanied by LOH at the MET6 locus indicating loss of the entire chr V | Tutaj H, et al. (2019) PMID:30244280 | |
| competitive fitness: decreased | competitive growth fitness profiling using complete deletion alleles | null Allele: sph1-Δ | S288C | Media: minimal medium Details: Relative fitness score: 0.975 | Breslow DK, et al. (2008) PMID:18622397 | |
| filamentous growth: decreased | systematic mutation set | null Allele: sph1-Δ | Sigma1278b | Jin R, et al. (2008) PMID:17989363 | ||
| haploproficient | heterozygous diploid, competitive growth | null Allele: sph1-Δ | S288C | Treatment: conditions that mimic Phase I of a batch fermentation, equivalent to ~14 hours after inoculation of a batch fermentation | Novo M, et al. (2013) PMID:24040173 | |
| mating projection morphology: abnormal | classical genetics | null Allele: sph1-Δ | S288C | Details: mating projections are more rounded than wild type | Roemer T, et al. (1998) PMID:9443897 | |
| mating projection morphology: abnormal | classical genetics | null Allele: sph1-Δ | W303 | Details: shmooing defects; form rounded or peanut-shaped morphology | Dittmar GA, et al. (2002) PMID:11923536 | |
| protein/peptide modification: decreased Reporter: Slt2p | classical genetics | null Allele: sph1-Δ | Other | Details: decreased levels of activated, phosphorylated Slt2p | Li X, et al. (2013) PMID:23924898 | |
| pseudohyphal growth: decreased | homozygous diploid | null Allele: sph1-Δ | Sigma1278b | Media: nitrogen starvation | Roemer T, et al. (1998) PMID:9443897 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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