TUB4 / YLR212C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Essential gene; heterozygous diploid null mutants have large cells with hyperelongated spindles and chromosome instability; phosphorylation mutants have abnormal spindles; repression mutants have abnormal mitochondria and arrest in M phase; conditional mutants grow slowly, have abnormally short anaphase spindles, and are sensitive to heat; activation mutants are resistant to microtubule-destabilizing agent benomyl

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources