Phenotype Help

ENT2 / YLR206W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.



Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

28 entries for 14 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
actin cytoskeleton morphology: abnormal
classical geneticsoverexpressionS288CDetails: see Table S7 for more details
Sopko R, et al. (2006) PMID:16455487
chronological lifespan: increased
competitive growth

competitive survival of stationary phase co-cultures

null
Allele: ent2-Δ
S288CGaray E, et al. (2014) PMID:24586198
competitive fitness: increased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: ent2-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 1.013
Breslow DK, et al. (2008) PMID:18622397
competitive fitness: increased
systematic mutation setnull
Allele: ent2-Δ
S288C ethanolQian W, et al. (2012) PMID:23103169
competitive fitness: increased
systematic mutation setnull
Allele: ent2-Δ
S288CMedia: glycerol medium, YPG
Qian W, et al. (2012) PMID:23103169
metal resistance: increased
systematic mutation set null
Allele: ent2-Δ
S288C3.9 mM gadolinium(3+)Treatment: gadolinium (III) chloride hexahydrate, 3.9 mM
Details: medium resistance; confirmed by serial dilution spot assays on 4.0 mM Gd
Grosjean N, et al. (2023) PMID:37630673
metal resistance: increased
classical genetics null
Allele: ent2-Δ
S288C4.0 mM gadolinium(3+)Treatment: gadolinium (III) chloride hexahydrate, 4.0 mM
Details: increased resistance to toxic concentrations of Gd for mutants in the endocytosis pathway; resistant to all light (La, Ce, Pr, Nd, Sm, Eu) and heavy (Tb, Dy, Ho, Er, Tm, Yb and Lu) rare earth elements
Grosjean N, et al. (2023) PMID:37630673
oxidative stress resistance: decreased
homozygous diploid, competitive growthnull
Allele: ent2-Δ
S288C3 mM hydrogen peroxideBrown JA, et al. (2006) PMID:16738548
oxidative stress resistance: increased
competitive growth null
Allele: ent2-Δ
S288C1 mM paraquatHelsen J, et al. (2020) PMID:32658971
replicative lifespan: increased
systematic mutation set null
Allele: ent2-Δ
S288CDetails: long-lived mutants, one standard deviation above the mean, were identified using an HTP sequencing-based yeast replicative lifespan screen (SEBYL), with pooled cells subject to four rounds of biotin-based sorting to enrich old vs young cells, followed by sequencing to ID mutants and abundance
Yu R, et al. (2021) PMID:33790287
Showing 1 to 10 of 28 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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