Protein Help

AVL9 / YLR114C Protein

Protein abundance data, domains, shared domains with other proteins, protein sequence retrieval for various strains, sequence-based physico-chemical properties, protein modification sites, and external identifiers for the protein.


Feature Type
ORF , Verified

AlphaFold Protein Structure

AlphaFold, developed by DeepMind, is an AI program that accurately predicts protein structures from amino acid sequences, enabling visualization of protein conformations. The predicted structures can be accessed through the Protein Data Bank (PDB) and AlphaFold Protein Structure Database.


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Model Confidence

Very high
Confident
Low
Very low

Experimental Data

Contains experimentally-derived protein half-life data obtained using stable isotope labeling by amino acids (SILAC) coupled with mass spectrometry. This section also contains protein abundance data for both untreated and treated cells obtained from over 20 studies. These data have been normalized and converted to a common unit of molecules per cell.


Protein Half Life

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ExperimentResultReference
half-life8.3 hrChristiano R, et al. (2014)

Protein Abundance

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Abundance (molecules/cell)MediaTreatmentTreatment timeFold ChangeVisualizationStrain backgroundOriginal ReferenceReference
3786SD2 mM 1,4-dithiothreitol2 hrconfocal microscopy evidenceS288CBreker M, et al. (2013)Ho B, et al. (2018)
3385SDuntreatedconfocal microscopy evidenceS288CChong YT, et al. (2015)Ho B, et al. (2018)
3109SD0.2 M hydroxyurea160 minconfocal microscopy evidenceS288CChong YT, et al. (2015)Ho B, et al. (2018)
2099SD200 ng/ml sirolimus700 min0.62confocal microscopy evidenceS288CChong YT, et al. (2015)Ho B, et al. (2018)
4167YEPDuntreatedflow cytometry evidenceS288CDavidson GS, et al. (2011)Ho B, et al. (2018)
Showing 1 to 5 of 26 entries

Domains and Classification - S288C

Collection of computationally identified domains and motifs, as determined by InterProScan analysis; includes protein coordinates for the domain, a domain Description, a Source and corresponding accession ID, and the number of S. cerevisiae genes that share the same domain.


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Gene Protein Coordinates Accession ID Description Source No. of Genes with Domain

Domain Locations

Visual representation of the locations of the domains within the protein, as listed in the Domains and Classification table. Each row displays the domain(s) derived from a different Source, with domains color-coded according to this Source.

Scroll over a domain to view its exact coordinates and its Description.

Shared Domains

This diagram displays domains (colored squares) shared between the given protein (yellow circle) and other proteins (gray circles); the domains are color-coded according to their source, as displayed in the Domain Locations table, above.

Reset

Click on a gene or domain name to go to its specific page within SGD; drag any of the gene or domain objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram.

Alleles

Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results.


avl9-Δ

View all AVL9 alleles in SGD search

Sequence

Protein sequence for the given gene in S288C and other strains, when available. Use the pull-down menu under "Strain" to select the sequence for a specific strain. The displayed sequence can be downloaded in FASTA format as a .txt file. Amino acids displayed in blue represent modification sites. More detailed evidence for these modification sites is presented in the Post-translational Modifications table, located just below the protein sequence.


1 MDEHEEAVIF GICLVDFHHK RGPEIEYWYG LPEGTQSAEL WPNLPFQALP DGSHSFEETF
61 TYFTLLYDER RQRSPPNGAT DLSDDSINDN TTLFAISCSR QIKSDELVTK DKDVTRSTVQ
121 KAIVVISRQP IFGQIKDKLS IVTNAFFLQH DFGDRKIIQS LYENLKSIYT PASLVRNAEN
181 RLYIGLCLRK ILHDFKRNAL VLLKAIMLEK KIIVYGNDVE ALCNLQFGLI SLIPDLMSNL
241 QDSGSPQLFQ DISKLNVVDS FKSSNRESVL RFLGFPLPIF EKGGLFSPYT PLQQMNDIRS
301 ERTLFFMIGS SNTLLAEQKE ELCHIFVNTD NSTVDILDKT LNPVLQLSSH DKKWIESISG
361 IVSDTWNEND DETPKNSQFE GSEDFIRWQF EDYLTGLLSS VKLSDYLDLH KENDQALKTI
421 PEDMLNSNPV HLFNLNWVQS WKETQNFLIF NSRTDDRLFD LFPPKHIYNG ADTLSLLQQR
481 FLATFHNLKR SSSNSSSNKN GHQSEEDIKD QESIESKKSV SQISVNPGKN TDKPAANLWN
541 SWKEYFNKPK NTANEDVTES TEDLKNRSKT SNAIQKAMMG LGLHYKPDAE TDQQSEEVGN
601 SEDNEDDDTD EDSEDDDDDG GDDDDSEDDD DDDDGEGDEN GDDGEGDENG DDGEGDENGD
661 KEDSQDFSNG FTDVTNINTD HDKENEQNFE GNAENFNEDE TVADKDIEGG PESNKNSDSK
721 TDIYENDRNV EDSSKTRNTV KKSNEEGGAN DAAIGNCVQD EEKL*

* Blue amino acids indicate modification sites. More information below.

Post-translational Modifications - S288C

Modification sites for the protein in the selected strain, based on the presence of a residue in the specific strain, as inferred from experimental evidence.

58 entries for 22 sites

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SiteModificationModifierReference
K110ubiquitinylated lysineBack S, et al. (2019) PMID: 30489083
S268phosphorylated residueLeutert M, et al. (2023) PMID: 37845410
S268phosphorylated residueLanz MC, et al. (2021) PMID: 33491328
T373phosphorylated residueLeutert M, et al. (2023) PMID: 37845410
T373phosphorylated residueLanz MC, et al. (2021) PMID: 33491328
S475phosphorylated residueLanz MC, et al. (2021) PMID: 33491328
S495phosphorylated residueLeutert M, et al. (2023) PMID: 37845410
S504phosphorylated residueLanz MC, et al. (2021) PMID: 33491328
S504phosphorylated residueLeutert M, et al. (2023) PMID: 37845410
S504phosphorylated residueMacGilvray ME, et al. (2020) PMID: 32597660
Showing 1 to 10 of 58 entries

Sequence-Based Physico-chemical Properties - S288C

Calculated protein properties, including amino acid composition, length, coding region calculations, and atomic composition.

Amino Acid Composition

Sort table using the arrow to the right of a column header to sort by that column; download all properties as a .txt file using the "Download Properties" button.

Amino AcidFrequencyPercentage
A273.53
C60.79
D8911.65
E678.77
F374.84
G435.63
H151.96
I425.50
K506.54
L678.77
M81.05
N648.38
P263.40
Q334.32
R243.14
S719.29
T405.24
V314.06
W91.18
Y151.96

Physical Details

Length (a.a): 764
Molecular Weight (Da): 86344.3
Isoelectric Point (pl): 4.11
Formula: C3750H5694N1022O1300S14
Aliphatic Index: 68.26
Instability Index: 45.21

Coding Region Translation Calculations

Codon Bias: -0.01
Codon Adaptation Index: 0.15
Frequence of Optimal Codons: 0.43
Hydropathicity of Protein: -0.85
Aromaticity Score: 0.08

Extinction Coefficients at 280nm

ALL Cys residues appear as half cystines: 72225.0
NO Cys residues appear as half cystines: 71850.0

Atomic Composition

Sort table using the arrow to the right of a column header to sort by that column; download all properties as a .txt file using the "Download Properties" button.

Atom Frequency Percentage

Data not found or not available for  S288C

External Identifiers

List of external identifiers for the protein from various database sources.

23 entries for 10 sources


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External IDSource
AN1018AspGD
orf19.6476CGD
4819DIP
6323143GenBank/EMBL/DDBJ
AAB67559.1GenBank/EMBL/DDBJ
CAA61692.1GenBank/EMBL/DDBJ
CAA97681.1GenBank/EMBL/DDBJ
X89514GenBank/EMBL/DDBJ
U53878GenBank/EMBL/DDBJ
Z73286GenBank/EMBL/DDBJ
Showing 1 to 10 of 23 entries

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