Protein abundance data, domains, shared domains with other proteins, protein sequence retrieval for various strains, sequence-based physico-chemical properties, protein modification sites, and external identifiers for the protein.
AlphaFold, developed by DeepMind, is an AI program that accurately predicts protein structures from amino acid sequences, enabling visualization of protein conformations. The predicted structures can be accessed through the Protein Data Bank (PDB) and AlphaFold Protein Structure Database.
Contains experimentally-derived protein half-life data obtained using stable isotope labeling by amino acids (SILAC) coupled with mass spectrometry. This section also contains protein abundance data for both untreated and treated cells obtained from over 20 studies. These data have been normalized and converted to a common unit of molecules per cell.
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Abundance (molecules/cell) | Media | Treatment | Treatment time | Fold Change | Visualization | Strain background | Original Reference | Reference |
---|---|---|---|---|---|---|---|---|
2012 | SD | untreated | quantitative mass spectrometry evidence | S288C | de Godoy LM, et al. (2008) | Ho B, et al. (2018) | ||
72 | YEPD | untreated | qualitative western immunoblotting evidence | S288C | Ghaemmaghami S, et al. (2003) | Ho B, et al. (2018) | ||
486 | YEPD | untreated | quantitative mass spectrometry evidence | S288C | Kulak NA, et al. (2014) | Ho B, et al. (2018) | ||
2753 | YEPD | untreated | quantitative mass spectrometry evidence | W303 | Nagaraj N, et al. (2012) | Ho B, et al. (2018) | ||
1259 | SC | untreated | quantitative mass spectrometry evidence | S288C | Peng M, et al. (2012) | Ho B, et al. (2018) |
Collection of computationally identified domains and motifs, as determined by InterProScan analysis; includes protein coordinates for the domain, a domain Description, a Source and corresponding accession ID, and the number of S. cerevisiae genes that share the same domain.
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Evidence ID | Analyze ID | Gene | Gene Systematic Name | Protein Coordinates | Accession ID | Description | Source | No. of Genes with Domain |
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Visual representation of the locations of the domains within the protein, as listed in the Domains and Classification table. Each row displays the domain(s) derived from a different Source, with domains color-coded according to this Source.
Scroll over a domain to view its exact coordinates and its Description.
Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results.
View all MNL2 alleles in SGD search
Protein sequence for the given gene in S288C and other strains, when available. Use the pull-down menu under "Strain" to select the sequence for a specific strain. The displayed sequence can be downloaded in FASTA format as a .txt file. Amino acids displayed in blue represent modification sites. More detailed evidence for these modification sites is presented in the Post-translational Modifications table, located just below the protein sequence.
This locus is not translated into a protein.
1 MSIARLVYSL FRRVRSVLLL FITISLLFYY TFQNEIDILN SYALNDSLPS INNYEHNTEG
61 SSKLDPPDLS STGSDRIATD KENGNVAVDL SDPATLREKN KYFPLLLKGS SHQIGSNLPI
121 SSLLTYKEKY PVLFEYSSPS LTSISQNDVH KIQPAMQLPP DVDMIKQIKD IFMKSWNQEQ
181 LLLKSNLRRE STWPIDLIDS LDTLYLCGET KLFQDSVNII EDFDFRVPPL AMEVIDIPDI
241 TTRVLEGLLS AYELSMDKRL LNKAKHVADF ILRSFDTPNR IPILKYFWKS DLRNRFPDRT
301 VPSGQLTTMA LAFIRLSQLT RLNKYFDAVE RVFTTIRQSY NEFDMEFMLP DVVDASGCQL
361 LTQEEIENGA HLKGSSIMKS INENFKFVHC QQLGKFLNPP IDDNSLQEQS QYQAYRINEK
421 TVPILENLFK INDLFQSSYD ILDGSSKNAN AATMDPSIGS EVEAVDEIIE KRNFKDGTKK
481 DSTKNTVGDK SLIDSQTFLT NSISNIFKFM TFRPMLPKQT ENKKFNFLNS ILTKSQFMPT
541 TNELDVTIRK SYDVSLYSCR LGGILGLSSR VPHRGGVNTK YILPSSLLEM SEIITESCFM
601 LMEEFDGLLP QKFELDPCTD ETNGNCEFNG ETKSRMIANG EYETFENDLD VGIKVSNYGK
661 GGNDQKAKRN VLSKDGITET QNIKGDTVGS SKSIAEIDGD EVTQIRRVFT LGKDIKPHIT
721 TDDTMGSQWK NHPDWPFWVN KVESRRLLDS NIIESIFYMY RISGEQKWRS MGKQSFGILM
781 QELMELNSGA KGLWQIKEFY ENGEKVNNDL PSYWFSRTLK YYLLLFSDGD KVSLDKHILT
841 QGGHIIKKK*
* Blue amino acids indicate modification sites. More information below.
Modification sites for the protein in the selected strain, based on the presence of a residue in the specific strain, as inferred from experimental evidence.
0 entries for 0 sitesIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
Calculated protein properties, including amino acid composition, length, coding region calculations, and atomic composition.
Sort table using the arrow to the right of a column header to sort by that column; download all properties as a .txt file using the "Download Properties" button.
Amino Acid | Frequency | Percentage |
---|---|---|
A | 24 | 2.83 |
C | 7 | 0.82 |
D | 61 | 7.18 |
E | 53 | 6.24 |
F | 44 | 5.18 |
G | 44 | 5.18 |
H | 11 | 1.30 |
I | 64 | 7.54 |
K | 63 | 7.42 |
L | 91 | 10.72 |
M | 23 | 2.71 |
N | 54 | 6.36 |
P | 35 | 4.12 |
Q | 34 | 4.00 |
R | 36 | 4.24 |
S | 81 | 9.54 |
T | 50 | 5.89 |
V | 37 | 4.36 |
W | 9 | 1.06 |
Y | 28 | 3.30 |
Length (a.a): | 849 |
Molecular Weight (Da): | 96983.2 |
Isoelectric Point (pl): | 5.37 |
Formula: | C4331H6794N1139O1325S30 |
Aliphatic Index: | 83.26 |
Instability Index: | 44.15 |
Codon Bias: | 0.05 |
Codon Adaptation Index: | 0.14 |
Frequence of Optimal Codons: | 0.46 |
Hydropathicity of Protein: | -0.41 |
Aromaticity Score: | 0.1 |
ALL Cys residues appear as half cystines: | 91595.0 |
NO Cys residues appear as half cystines: | 91220.0 |
Sort table using the arrow to the right of a column header to sort by that column; download all properties as a .txt file using the "Download Properties" button.
Atom | Frequency | Percentage |
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Data not found or not available for S288C
List of external identifiers for the protein from various database sources.
23 entries for 7 sourcesIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
External ID | Source |
---|---|
8921 | DIP |
6323086 | GenBank/EMBL/DDBJ |
CAA97587.1 | GenBank/EMBL/DDBJ |
CAA97589.1 | GenBank/EMBL/DDBJ |
CAA64304.1 | GenBank/EMBL/DDBJ |
AAT92576.1 | GenBank/EMBL/DDBJ |
AY692557 | GenBank/EMBL/DDBJ |
X94607 | GenBank/EMBL/DDBJ |
Z73230 | GenBank/EMBL/DDBJ |
Z73229 | GenBank/EMBL/DDBJ |
AGD | AnalogYeast | BLASTP at NCBI | FungiDB | PhylomeDB | YGOB | YOGY
AlphaFold Protein Structure | GPMDB | ModelArchive | Pfam domains | SUPERFAMILY | TopologYeast | UniProtKB
CYCLoPs | dHITS | LoQAtE | YeastGFP | YeastRGB | YPL+